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Technologies capable of characterizing the full breadth of cellular systems need to be able to measure millions of proteins, isoforms, and complexes simultaneously. We describe an approach that fulfils this

Technologies capable of characterizing the full breadth of cellular systems need to be able to measure millions of proteins, isoforms, and complexes simultaneously. We describe an approach that fulfils this criterion: Adaptive Dynamic Artificial Poly-ligand Targeting (ADAPT). ADAPT employs an enriched library of single-stranded oligodeoxynucleotides (ssODNs) to profile complex biological samples, thus achieving an unprecedented coverage of system-wide, native biomolecules.

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    Date Created
    • 2017-02-20
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  • Text
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    Identifier
    • Digital object identifier: 10.1038/srep42741
    • Identifier Type
      International standard serial number
      Identifier Value
      2045-2322
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    Domenyuk, V., Zhong, Z., Stark, A., Xiao, N., O’Neill, H. A., Wei, X., . . . Spetzler, D. (2017). Plasma Exosome Profiling of Cancer Patients by a Next Generation Systems Biology Approach. Scientific Reports, 7, 42741. doi:10.1038/srep42741

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