Description
We used sex, observed parenting quality at 18 months, and three variants of the catechol-O-methyltransferase gene (Val[superscript 158]Met [rs4680], intron1 [rs737865], and 3′-untranslated region [rs165599]) to predict mothers' reports of inhibitory and attentional control (assessed at 42, 54, 72, and

We used sex, observed parenting quality at 18 months, and three variants of the catechol-O-methyltransferase gene (Val[superscript 158]Met [rs4680], intron1 [rs737865], and 3′-untranslated region [rs165599]) to predict mothers' reports of inhibitory and attentional control (assessed at 42, 54, 72, and 84 months) and internalizing symptoms (assessed at 24, 30, 42, 48, and 54 months) in a sample of 146 children (79 male). Although the pattern for all three variants was very similar, Val[superscript 158]Met explained more variance in both outcomes than did intron1, the 3′-untranslated region, or a haplotype that combined all three catechol-O-methyltransferase variants. In separate models, there were significant three-way interactions among each of the variants, parenting, and sex, predicting the intercepts of inhibitory control and internalizing symptoms. Results suggested that Val[superscript 158]Met indexes plasticity, although this effect was moderated by sex. Parenting was positively associated with inhibitory control for methionine–methionine boys and for valine–valine/valine–methionine girls, and was negatively associated with internalizing symptoms for methionine–methionine boys. Using the “regions of significance” technique, genetic differences in inhibitory control were found for children exposed to high-quality parenting, whereas genetic differences in internalizing were found for children exposed to low-quality parenting. These findings provide evidence in support of testing for differential susceptibility across multiple outcomes.
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Title
  • Interactions among catechol-O-methyltransferase genotype, parenting, and sex predict children's internalizing symptoms and inhibitory control: Evidence for differential susceptibility
Date Created
2015-08-01
Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1017/S0954579414000807
    • Identifier Type
      International standard serial number
      Identifier Value
      0954-5794
    • Identifier Type
      International standard serial number
      Identifier Value
      1469-2198
    Note
    • This is the authors' final manuscript as accepted. The final published version can be viewed at DEVELOPMENT AND PSYCHOPATHOLOGY / Volume 27 / Issue 3 / 2015-08-01, pp 709-723 Copyright Cambridge University Press 2015 DOI: 10.1017/S0954579414000807

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    Sulik, Michael J., Eisenberg, Nancy, Spinrad, Tracy L., Lemery-Chalfant, Kathryn, Swann, Gregory, Silva, Kassondra M., Reiser, Mark, Stover, Daryn A., & Verrelli, Brian C. (2015). Interactions among catechol-O-methyltransferase genotype, parenting, and sex predict children's internalizing symptoms and inhibitory control: Evidence for differential susceptibility. DEVELOPMENT AND PSYCHOPATHOLOGY, 27(3), 709-723. http://dx.doi.org/10.1017/S0954579414000807

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