Recent infectious outbreaks highlight the need for platform technologies that can be quickly deployed to develop therapeutics needed to contain the outbreak. We present a simple concept for rapid development of new antimicrobials. The goal was to produce in as little as one week thousands of doses of an intervention for a new pathogen. We tested the feasibility of a system based on antimicrobial synbodies. The system involves creating an array of 100 peptides that have been selected for broad capability to bind and/or kill viruses and bacteria.
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- Johnston, Stephen (Contributor)
- Domenyuk, Valeriy (Contributor)
- Gupta, Nidhi (Contributor)
- Tavares Batista, Milene (Contributor)
- Lainson, John (Contributor)
- Zhao, Zhan-Gong (Contributor)
- Lusk, Joel (Contributor)
- Loskutov, Andrey (Contributor)
- Cichacz, Zbigniew (Contributor)
- Stafford, Phillip (Contributor)
- Legutki, Joseph Barten (Contributor)
- Diehnelt, Chris (Contributor)
- Biodesign Institute (Contributor)
- 2017-12-14
- Digital object identifier: 10.1038/s41598-017-17941-7
- Identifier TypeInternational standard serial numberIdentifier Value2045-2322
- The final version of this article, as published in Scientific Reports, can be viewed online at: http://www.nature.com/articles/s41598-017-17941-7, opens in a new window
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Johnston, S. A., Domenyuk, V., Gupta, N., Batista, M. T., Lainson, J. C., Zhao, Z., . . . Diehnelt, C. W. (2017). A Simple Platform for the Rapid Development of Antimicrobials. Scientific Reports, 7(1). doi:10.1038/s41598-017-17941-7