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Background:
Grading schemes for breast cancer diagnosis are predominantly based on pathologists' qualitative assessment of altered nuclear structure from 2D brightfield microscopy images. However, cells are three-dimensional (3D) objects with

Background:
Grading schemes for breast cancer diagnosis are predominantly based on pathologists' qualitative assessment of altered nuclear structure from 2D brightfield microscopy images. However, cells are three-dimensional (3D) objects with features that are inherently 3D and thus poorly characterized in 2D. Our goal is to quantitatively characterize nuclear structure in 3D, assess its variation with malignancy, and investigate whether such variation correlates with standard nuclear grading criteria.

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    Date Created
    • 2012-01-05
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1371/journal.pone.0029230
    • Identifier Type
      International standard serial number
      Identifier Value
      1045-3830
    • Identifier Type
      International standard serial number
      Identifier Value
      1939-1560

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    Nandakumar, V., Kelbauskas, L., Hernandez, K. F., Lintecum, K. M., Senechal, P., Bussey, K. J., . . . Meldrum, D. R. (2012). Isotropic 3D Nuclear Morphometry of Normal, Fibrocystic and Malignant Breast Epithelial Cells Reveals New Structural Alterations. PLoS ONE, 7(1). doi:10.1371/journal.pone.0029230

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