While REM Sleep Behavior disorder (RBD) has been linked with synucleinopathies, difficulties persist in clinically convenient diagnostic tools which can differentiate between underlying diseases. Identifying markers in the gait of RBD patients may ease the diagnostic process and indicate potential or status for developing more severe disorders. Individuals were referred to Movement Disorders Center of Arizona (MDCA) by a sleep specialist with a confirmed diagnosis of RBD, or those who were clinically indicated after questioning. All participants underwent a skin-biopsy test for α-synuclein, I-ioflupane dopamine transporter(DAT) scan, and had their gait velocity, cadence and stride dynamics assessed by an automated gait analysis system.

The goal of this work is to develop a portable and accurate colorblind test that has advantages over the HRR and Ishihara plate tests, including that it is easier and faster to perform, does not require the subject to identify alphanumeric characters or geometric shapes, provides unambiguous results to the provider without interpretation, and is at least 8 times faster. The advantage over prior anomaloscopes is that it can be made in a hand-held version, uses binary matching choices rather than having the subject match colors with a tuning knob, and uses optimal reference color choices determined from established knowledge of human color perception. To successfully achieve this, cone spectral sensitivity curves and all subsets of four LEDs from a set of eight spanning the visible spectrum, the 1x4 metamer solution for a reference color for normal vision, deuteranomaly, and protanomaly are calculated. From these solutions, the optimized set of 4 LEDS was determined by maximizing the average angle between the normal, deuteranomaly, and protanomaly metamer solution vectors in the XYZ color space. To perform the test, the subject is asked to determine the best match for color and brightness in side-by-side display panels illuminated with distinctly different reference metamer color pairs for normal, deuteranomaly, and protanomaly vision. This allows the operator to directly and unambiguously determine the subject’s color vision type. The average duration to perform the tests are 30, 253, and 281 seconds for the anomaloscope, Ishihara 38 plate test, and HRR 24 plate test, respectively. When determining whether the subject has normal vision or is colorblind, the anomaloscope and HRR test results agreed for all 102 subjects. Because this rendition of the anomaloscope was designed to only distinguish between normal, deuteranomalous, and protanomalous vision, the 7 subjects that the HRR determined to be tritanomalous were not included in the results presented hereafter. The HRR 24 plate test and the anomaloscope agreed in their diagnosis 91/95 = 96% of the time, the Ishihara 38 plate test and the anomaloscope agreed in their diagnosis 94/101 = 93% of the time, and the HRR and the Ishihara agreed in their diagnosis 89/95 = 94% of the time. The approach described here can be extended to other types of color blindness.

This creative project develops an environment in which three species inhabit a shared land and models the movement of the creatures to determine the survival rates over time in specific conditions. The three species modelled include a predator and a prey species with movement capabilities as well as a stagnant fruit species. There are a variety of configurable variables that can be used to modify and control the simulation to observe how the resulting population charts change. The big difference between this project and a normal approach to simulating a predation relationship is that actual creatures themselves are being created and their movement is simulated in this virtual environment which then leads to population counts, rather than integrating differential equations relating the population sizes of both species and purely tracking the populations but not the creatures themselves. Because of this difference, my simulation is not meant to handle all the complexities of life that come in the real-world but instead is intended as a simplified approach to simulating creatures' lives with the purpose of conveying the idea of a real predation relationship. Thus, the main objective of my simulation is to produce data representative of real-world predator-prey relationships, with the overall cyclical pattern that is observed in natural achieved through simulating creature movement and life itself rather than estimating population size change.

In this project, we aim to fabricate PIN structure-like diodes for radiation detectors using Boron Nitride (BN). This fabrication is done by performing lithography and metal deposition processes on a Cubic Boron Nitride (cBN) of around 200 nm in thickness layer on top of a boron doped diamond substrate. The main goal is to create the most efficient and affordable alpha particle—and ideally neutron—detector in a radiation setting. Thus, making more accessible radiation detectors that can be more easily produced and disposed of, as well as minimizing the size of conventional detectors.

Advances in photoinjector technology have given rise to applications such as XFELs, UED, and UEM. Brighter electron beams from the source increase pulse energies and photon lasing energies for XFELs, as well as an increase in coherence lengths at femtosecond timescales on the Ultrafast Electron technologies. Deeper investigations of the photoemission process have placed stringent requirements on electron sources for next generation electron accelerator technology, and certain novel photocathode sources have been identified as candidates to satisfy these required specifications. At Arizona State University, a cryogenically cooled 200 kV DC electron gun and accompanying photocathode diagnostics beamline was developed and conditioned specifically to implement these novel photocathodes and provide diagnostics for their performance.