The Implications of Muscle Sarcoplasm Adaptations on Athletic Performance

Description
I researched and discussed the background of muscular hypertrophy as well as the potential mechanisms of sarcoplasmic hypertrophy. I proposed a hypothetical study that could help distinguish the effects of strength versus fatigue training and identified the impact of some

I researched and discussed the background of muscular hypertrophy as well as the potential mechanisms of sarcoplasmic hypertrophy. I proposed a hypothetical study that could help distinguish the effects of strength versus fatigue training and identified the impact of some key variables on muscle hypertrophy. The outcome of this hypothetical study could help improve the way athletes train in order to better suit their specific performance needs.
Date Created
2024-05
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Girlhood: A Collection of Short Stories

Description
Two short stories that span the adolescent and early adulthood genre, demonstrating appropriate voice to the age level and adolescent developmental challenges.
Date Created
2024-05
Agent

Investigating the Potential Neuroprotective Effects of ACMSD Across Sex in P301S Mice

Description
The kynurenine pathway (KP) is a biosynthetic pathway for the catabolism of tryptophan, the amino acid precursor to serotonin. The KP has been linked to neuroinflammation, as inflammatory agents upregulate an early enzyme in the pathway (Davis & Liu, 2015;

The kynurenine pathway (KP) is a biosynthetic pathway for the catabolism of tryptophan, the amino acid precursor to serotonin. The KP has been linked to neuroinflammation, as inflammatory agents upregulate an early enzyme in the pathway (Davis & Liu, 2015; Wang et al., 2009). In addition, the metabolite quinolinic acid (QA) has been found to induce tau phosphorylation and excess glutamate release, inducing further neuroinflammation (Guillemin, 2012; Rahman et al., 2009). However, in the presence of 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD), the KP shifts away from QA production towards that of picolinic acid (PA), a metabolite with antimicrobial and antiviral properties. Our lab has previously shown that overexpressing ACMSD via adeno-associated virus (AAV) delivery in the alpha-synuclein (α -syn) model of Parkinson's disease (PD) animal model exhibits neuroprotective effects by preventing the loss of dopaminergic neurons in the substantia nigra and limiting motor impairments caused by nigrostriatal denervation. Based on these findings, we predicted that ACMSD would provide neuroprotective effects in the P301S tauopathy model of neurodegenerative disease, a mouse model of frontotemporal dementia (FTD). Specifically, we hypothesized that ACMSD would ameliorate behavioral deficits, including those related to cognitive and emotional processing. We also predicted that ACMSD overexpression would prevent histological indices of pathology, including the expression of hyperphosphorylated tau, gliosis, and neurodegeneration. As previous findings in the literature have denoted sex differences in pathological outcomes of the P301S mouse model (Sun et al., 2020) with males showing more pronounced behavioral deficits and increased hyperphosphorylated tau than females, we hypothesized that ACMSD would show a higher degree of neuroprotection in male P301S mice. P301S and litter/age-matched wild-type controls underwent stereotaxic surgery at two months of age prior to pathological onset to deliver either an AAV-dHS-ACMSD or AAV-dHS-GFP (control) to the dorsal hippocampus. Prior to euthanasia, the mice underwent the Barnes maze test to assess cognitive function focusing on learning and memory recall. Analysis of this assay revealed that male P301S mice treated with ACMSD displayed a trend toward shorter latency in locating the escape hatch during the Barnes Maze test than untreated males, albeit not significant, suggesting a potential enhancement in spatial learning. At eight and a half months, the mice were killed, and their brains harvested. The tissue underwent immunohistochemistry staining for a marker of hyperphosphorylated tau (AT8), markers of gliosis (Iba1 and GFAP), and the pan-neuronal marker (HuC/D) to quantify pathological indices. Preliminary histological analyses show decreased immunoreactivity of AT8 in the hippocampus of P301S mice injected with ACMSD, compared to those injected with GFP control, indicating potential neuroprotective effects by limiting the amount of hyperphosphorylated tau.
Date Created
2024-05
Agent

Border To Border: Creating A Theoretical Early Child Development Intervention Program for Refugees in Mexico Using Theory of Change Models

Description
Using existing research on refugee populations in Mexico, theory of change models were created to model a potential early childhood development program for refugee children ages 0-5 in Mexico. The populations taken into consideration were refugees in Mexico from other

Using existing research on refugee populations in Mexico, theory of change models were created to model a potential early childhood development program for refugee children ages 0-5 in Mexico. The populations taken into consideration were refugees in Mexico from other Latin American countries, refugees migrating through Mexico towards the northern border, and refugees who had crossed/were crossing the border into the United States.
Date Created
2024-05
Agent

WHEN PRESENTED WITH INTROSPECTION; OUR TERRITORIAL SELF

Description
What does self love look like when visualized? What does self hate look like when visualized? What is the frustration one experiences when introspecting, and how can that be represented in art? Complex matters of identity such as this often

What does self love look like when visualized? What does self hate look like when visualized? What is the frustration one experiences when introspecting, and how can that be represented in art? Complex matters of identity such as this often involve an ambiguous, non-linear approach to self understanding, making the medium of animation particularly apt for this exploration. This film aims to observe feelings of self-dysphoria and the surges of discomfort and acceptance that come with them.
Date Created
2024-05
Agent

whos-in-charge_-a-critical-analysis-of-arizona-school-boards-and-experiential-decision-making_0.pdf

Date Created
2024-05
Agent

Who’s In Charge? A Critical Analysis of Arizona School Boards and the Influence of Educational
Background and Political Partisanship on Decision-Making

Description
This thesis project explores the extent to which elected education officials, specifically school board members, with a background in education make policy decisions differently than those who do not have a background in education. This line of questioning began with

This thesis project explores the extent to which elected education officials, specifically school board members, with a background in education make policy decisions differently than those who do not have a background in education. This line of questioning began with a project completed in a class I took in the fall semester of 2023 - Innovations in School Democracy, where students chose a critical issue in the education sphere and situated it within the context of civic education. The critical issue I addressed at the time was the significant number of individuals in “high-ranking” positions in the education field who do not appear to have a background in anything education-related, outside of their own schooling. The issue lies with the fact that these individuals are making large scale policy decisions that impact all students, teachers, parents, and school faculty members within their district without having any research or practice-based educational foundation or experience to draw upon for their decision making. For the purpose of this thesis, I expanded this phenomenon beyond the realm of civic education by performing a comparative analysis of elected education official decision-making between school boards that have members with educational backgrounds and those who don’t, in addition to analyzing the stances and policies of the Superintendent of Public Instruction. The goal of this analysis is to see how, or if, decisions differ and to what extent those decisions appear to be driven by current political ideologies versus educational research and best practices. I hypothesize that elected education officials who have a background in education will make decisions that are more student- and educator-focused and have fewer indicators of a specific partisan political ideology. Conversely, I hypothesize the opposite for decision-making by officials without an education background, where I expect to find more evidence of influential partisan political ideology. In order to determine if a decision-making gap exists, I examined school board websites and pulled district-related news articles in order to cross-analyze the verbiage on specific political buzzwords or phrases that could be clearly linked to a political party’s ideology or stance on public schooling matters and policies. I performed a similar search through the campaign platform and current Arizona Education System biographical page for Superintendent Tom Horne. To begin this investigation, thirty school districts in the state of Arizona were selected for preliminary research - ten small districts, ten medium-size districts, and ten large districts. Through the use of school district websites and the biographies of school board members, I determined which school boards had individuals with a background in education and which did not. From there, two school boards from each district size category were selected for examination - one board categorized as having a strong educational background presence and one board that either had very minimal presence, or none at all. From this research, I intended to present preliminary findings about the extent to which differences in policy-making decisions relate to school board member education background and experience, as well as the degree to which explicit partisan politicization appears to influence such decisions. Upon completion of this limited research, my findings ended up deriving more directly from the mission and vision statements of school districts and school boards, though policy decisions were still loosely analyzed through district media articles. However, my research on Superintendent Horne lent itself well to answer all three of my proposed research questions.
Date Created
2024-05
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