Description
Mitochondria produce most of the ATP needed for the cell as an energy source. It is well known that cellular respiration results in oxidative damage to the cell due to the production of reactive oxygen species (ROS). Mitochondrial dysfunction is believed to contribute to a number of degenerative diseases; because of this the mitochondrial respiratory chain is considered as potential drug target. A few series of idebenone analogues with quinone, pyridinol and pyrimidinol redox cores have been synthesized and evaluated as antioxidants able to protect cellular integrity and, more specifically, mitochondrial function. The compounds exhibited a range of activities. The activities observed were used for the design of analogues with enhanced properties as antioxidants. Compounds were identified which provide better protection against oxidative stress than idebenone, and it is thought that they do so catalytically.
Details
Title
- Synthesis of multifunctional radical quenchers (MRQ's)
Contributors
- Arce Amezquita, Pablo M (Author)
- Hecht, Sidney M. (Thesis advisor)
- Moore, Ana (Committee member)
- Rose, Seth (Committee member)
- Arizona State University (Publisher)
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2012
Subjects
Resource Type
Collections this item is in
Note
- thesisPartial requirement for: Ph.D., Arizona State University, 2012
- bibliographyIncludes bibliographical references (p. 183-190)
- Field of study: Chemistry
Citation and reuse
Statement of Responsibility
by Pablo M. Arce Amezquita