Protein folding is essential in all cells, and misfolded proteins cause many diseases. In the Gram-negative bacterium Escherichia coli, protein folding must be carefully controlled during envelope biogenesis to maintain an effective permeability barrier between the cell and its environment. This study explores the relationship between envelope biogenesis and cell stress, and the return to homeostasis during envelope stress. A major player in envelope biogenesis and stress response is the periplasmic protease DegP.
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- Partial requirement for: Ph.D., Arizona State University, 2010Note typethesis
- Includes bibliographical references (p. 142-168)Note typebibliography
- Field of study: Microbiology