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Protein folding is essential in all cells, and misfolded proteins cause many diseases. In the Gram-negative bacterium Escherichia coli, protein folding must be carefully controlled during envelope biogenesis to

Protein folding is essential in all cells, and misfolded proteins cause many diseases. In the Gram-negative bacterium Escherichia coli, protein folding must be carefully controlled during envelope biogenesis to maintain an effective permeability barrier between the cell and its environment. This study explores the relationship between envelope biogenesis and cell stress, and the return to homeostasis during envelope stress. A major player in envelope biogenesis and stress response is the periplasmic protease DegP.

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    Date Created
    • 2010
    Resource Type
  • Text
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    Note
    • Partial requirement for: Ph.D., Arizona State University, 2010
      Note type
      thesis
    • Includes bibliographical references (p. 142-168)
      Note type
      bibliography
    • Field of study: Microbiology

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    Owen Paul Leiser

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