Description
Doxorubicin (DOX) is a cardiotoxic, anthracycline-based, anti-neoplastic agent that causes pathological cardiac remodeling due to altered protein expression associated with cardiotoxicity. DOX cardiotoxicity causes increased Akt phosphorylation, blunted AMPK phosphorylation and upregulated mTOR phosphorylation. Akt is activated by cellular stress and damage.
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Contributors
- Panknin, Timothy M (Author)
- Angadi, Siddhartha (Thesis director)
- Sweazea, Karen (Committee member)
- Dickinson, Jared (Committee member)
- School of Nutrition and Health Promotion (Contributor)
- Barrett, The Honors College (Contributor)
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The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2017-05
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