Description

We compare three schemes for time-resolved X-ray diffraction from protein nanocrystals using an X-ray free-electron laser. We find expressions for the errors in structure factor measurement using the Monte Carlo

We compare three schemes for time-resolved X-ray diffraction from protein nanocrystals using an X-ray free-electron laser. We find expressions for the errors in structure factor measurement using the Monte Carlo pump-probe method of data analysis with a liquid jet, the fixed sample pump-probe (goniometer) method (both diffract-and-destroy, and below the safe damage dose), and a proposed two-color method. Here, an optical pump pulse arrives between X-ray pulses of slightly different energies which hit the same nanocrystal, using a weak first X-ray pulse which does not damage the sample.

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    Date Created
    • 2015-06-12
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1063/1.4922433
    • Identifier Type
      International standard serial number
      Identifier Value
      2329-7778

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    Li, C., Schmidt, K., & Spence, J. C. (2015). Data collection strategies for time-resolved X-ray free-electron laser diffraction, and 2-color methods. Structural Dynamics, 2(4), 041714. doi:10.1063/1.4922433

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