Description

Signaling cascades proliferate signals received on the cell membrane to the nucleus. While noise filtering, ultra-sensitive switches, and signal amplification have all been shown to be features of such signaling

Signaling cascades proliferate signals received on the cell membrane to the nucleus. While noise filtering, ultra-sensitive switches, and signal amplification have all been shown to be features of such signaling cascades, it is not understood why cascades typically show three or four layers. Using singular perturbation theory, Michaelis–Menten type equations are derived for open enzymatic systems. Cascading these equations we demonstrate that the output signal as a function of time becomes sigmoidal with the addition of more layers.

application/pdf

Download count: 0

Details

Contributors
Date Created
  • 2014-11-21
Resource Type
  • Text
  • Collections this item is in
    Identifier
    • Digital object identifier: 10.1016/j.jtbi.2014.07.012
    • Identifier Type
      International standard serial number
      Identifier Value
      0022-5193
    Note

    Citation and reuse

    Cite this item

    This is a suggested citation. Consult the appropriate style guide for specific citation guidelines.

    Armbruster, Dieter, Nagy, John, & Young, Jon (2014). Three level signal transduction cascades lead to reliably timed switches. JOURNAL OF THEORETICAL BIOLOGY, 361, 69-80. http://dx.doi.org/10.1016/j.jtbi.2014.07.012

    Machine-readable links