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Natural selection among tumor cell clones is thought to produce hallmark properties of malignancy. Efforts to understand evolution of one such hallmark—the angiogenic switch—has suggested that selection for angiogenesis can

Natural selection among tumor cell clones is thought to produce hallmark properties of malignancy. Efforts to understand evolution of one such hallmark—the angiogenic switch—has suggested that selection for angiogenesis can “run away” and generate a hypertumor, a form of evolutionary suicide by extreme vascular hypo- or hyperplasia. This phenomenon is predicted by models of tumor angiogenesis studied with the techniques of adaptive dynamics.

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    • 2014-04-14
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    Bickel, S. T., Juliano, J. D., & Nagy, J. D. (2014). Evolution of Proliferation and the Angiogenic Switch in Tumors with High Clonal Diversity. PLoS ONE, 9(4). doi:10.1371/journal.pone.0091992

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