Accumulating data from genome-wide association studies (GWAS) have provided a collection of novel candidate genes associated with complex diseases, such as atherosclerosis. We identified an atherosclerosis-associated single-nucleotide polymorphism (SNP) located in the intron of the long noncoding RNA (lncRNA) LINC00305 by searching the GWAS database. Although the function of LINC00305 is unknown, we found that LINC00305 expression is enriched in atherosclerotic plaques and monocytes.
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- Zhang, Dan-Dan (Author)
- Wang, Wen-Tian (Author)
- Xiong, Jian (Author)
- Xie, Xue-Min (Author)
- Cui, Shen-Shen (Author)
- Zhao, Zhi-Guo (Author)
- Li, Mulin Jun (Author)
- Zhang, Zhu-Qin (Author)
- Hao, De-Long (Author)
- Zhao, Xiang (Author)
- Li, Yong-Jun (Author)
- Wang, Junwen (Contributor)
- Chen, Hou-Zao (Author)
- Lv, Xiang (Author)
- Liu, De-Pei (Author)
- College of Health Solutions (Contributor)
- 2017-04-10
- Digital object identifier: 10.1038/srep46204
- Identifier TypeInternational standard serial numberIdentifier Value2045-2322
- The final version of this article, as published in Scientific Reports, can be viewed online at: http://www.nature.com/articles/srep46204, opens in a new window
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Zhang, D., Wang, W., Xiong, J., Xie, X., Cui, S., Zhao, Z., . . . Liu, D. (2017). Long noncoding RNA LINC00305 promotes inflammation by activating the AHRR-NF-κB pathway in human monocytes. Scientific Reports, 7, 46204. doi:10.1038/srep46204