Description

Mof4 family associated protein 1 (MRFAP1) is a 14 kDa nuclear protein, which involves in maintaining normal histone modification levels by negatively regulating recruitment of the NuA4 (nucleosome acetyltransferase of

Mof4 family associated protein 1 (MRFAP1) is a 14 kDa nuclear protein, which involves in maintaining normal histone modification levels by negatively regulating recruitment of the NuA4 (nucleosome acetyltransferase of H4) histone acetyltransferase complex to chromatin. MRFAP1 has been identified as one of the most up-regulated proteins after NEDD8 (neural precursor cell expressed developmentally down- regulated 8) inhibition in multiple human cell lines. However, the biological function of MRFAP1 and the E3 ligase that targets MRFAP1 for destruction remain mysterious.

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    Date Created
    • 2017-10-12
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  • Text
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    Identifier
    • Digital object identifier: 10.18632/oncotarget.21843
    • Identifier Type
      International standard serial number
      Identifier Value
      1949-2553
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    Li, D., Liu, S., Zhu, L., Wang, Y., Chen, Y., Liu, J., . . . Liu, B. (2017). FBXW8-dependent degradation of MRFAP1 in anaphase controls mitotic cell death. Oncotarget, 8(57). doi:10.18632/oncotarget.21843

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