Cocaine abuse affects millions of people with disastrous medical and societal consequences. Despite this, there is still no FDA-approved treatment to decrease the likelihood of relapse in rehabilitated addicts, and acute cocaine toxicity (overdose) is only symptomatically treated. Studies have demonstrated a promising potential treatment option with the help of the human serum enzyme butyrylcholinesterase (BChE), an enzyme capable of breaking down cocaine into biologically inactive side products. This activity of wild-type BChE, however, is relatively low.
Download count: 0
- Molecular Biology
- Cellular Biology
- Cocaine Hydrolase
- Plant-derived Pharmaceutical
- Materia medica, Vegetable--Molecular aspects.
- Materia medica, Vegetable
- Cocaine abuse--Treatment.
- Butyrylcholinesterase--Molecular aspects.
- Partial requirement for: Ph.D., Arizona State University, 2015Note typethesis
- Includes bibliographical references (pages 164-190)Note typebibliography
- Field of study: Molecular and cellular biology