Defining the effects of ERK/MAPK hyperactivation on the development of GABAergic

Abstract: The RAS/RAF/MEK/ERK (RAS signaling cascade) pathway is a highly conserved biochemical signaling cascade that exists in every mammalian cell. The pathway is highly versatile in functionality due to hundreds of substrates that regulate metabolism, apoptosis, and proliferation in both adult and developing tissues. The RAS signaling cascade has been examined in the context of cancers since mutations can lead to the disruption of the cell cycle and unregulated cellular proliferation.