Refining the structure of hPIRT, a modulator of TRP channels, via measurement of residual dipolar couplings in nuclear magnetic resonance spectroscopy

Transient receptor potential channels (TRP channels) are a family of ion channels that mediate a wide variety of sensations, including pain, temperature, and mechanosensation. Human phosphoinositide-interacting regulator of TRP (hPIRT) is a 15.5 kDa, relatively uncharacterized membrane protein that has been shown to modulate the activity of certain TRP channels and some other ion channels.