Description
Vaccinia virus is a cytoplasmic, double-stranded DNA orthopoxvirus. Unlike mammalian cells, vaccinia virus produces double-stranded RNA (dsRNA) during its viral life cycle. The protein kinase R, PKR, is one of the principal host defense mechanisms against orthopoxvirus infection. PKR can bind double-stranded RNA and phosphorylate eukaryotic translation initiation factor, eIF2α, shutting down protein synthesis and halting the viral life cycle. To combat host defenses, vaccinia virus encodes E3, a potent inhibitor of the cellular anti-viral eIF2α kinase, PKR.
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Contributors
- Foster, Clayton (Co-author)
- Alattar, Hamed (Co-author)
- Jacobs, Bertram (Thesis director)
- Blattman, Joseph (Committee member)
- McFadden, Grant (Committee member)
- School of Life Sciences (Contributor)
- W. P. Carey School of Business (Contributor)
- Department of Psychology (Contributor)
- Barrett, The Honors College (Contributor)
Date Created
- 2017-05
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