Codon Optimization of Human TRAIL Gene for Maximal Expression in a Self-Destructing Salmonella Strain for Efficient Colorectal Cancer Treatment

Colorectal cancer is the third most common type of cancer that affects both men and women and the second leading cause of death in cancer related deaths[1, 2]. The most common form of treatment is chemotherapy followed by radiation, which is insufficient to cure stage four cancers[3].