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Mammalian telomeres are specialized chromatin structures that require the telomere binding protein, TRF2, for maintaining chromosome stability. In addition to its ability to modulate DNA repair activities, TRF2 also has

Mammalian telomeres are specialized chromatin structures that require the telomere binding protein, TRF2, for maintaining chromosome stability. In addition to its ability to modulate DNA repair activities, TRF2 also has direct effects on DNA structure and topology. Given that mammalian telomeric chromatin includes nucleosomes, we investigated the effect of this protein on chromatin structure. TRF2 bound to reconstituted telomeric nucleosomal fibers through both its basic N-terminus and its C-terminal DNA binding domain.

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    Date Created
    • 2011-04-19
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1371/journal.pone.0019124
    • Identifier Type
      International standard serial number
      Identifier Value
      1045-3830
    • Identifier Type
      International standard serial number
      Identifier Value
      1939-1560

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    Baker, A. M., Fu, Q., Hayward, W., Victoria, S., Pedroso, I. M., Lindsay, S. M., & Fletcher, T. M. (2011). The Telomere Binding Protein TRF2 Induces Chromatin Compaction. PLoS ONE, 6(4). doi:10.1371/journal.pone.0019124

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