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Swinging arms are a key functional component of multistep catalytic transformations in many naturally occurring multi-enzyme complexes. This arm is typically a prosthetic chemical group that is covalently attached to

Swinging arms are a key functional component of multistep catalytic transformations in many naturally occurring multi-enzyme complexes. This arm is typically a prosthetic chemical group that is covalently attached to the enzyme complex via a flexible linker, allowing the direct transfer of substrate molecules between multiple active sites within the complex. Mimicking this method of substrate channelling outside the cellular environment requires precise control over the spatial parameters of the individual components within the assembled complex.

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Date Created
  • 2014-07-01
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  • Text
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    Identifier
    • Digital object identifier: 10.1038/NNANO.2014.100
    • Identifier Type
      International standard serial number
      Identifier Value
      1748-3387
    • Identifier Type
      International standard serial number
      Identifier Value
      1748-3395
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    Fu, Jinglin, Yang, Yuhe Renee, Johnson-Buck, Alexander, Liu, Minghui, Liu, Yan, Walter, Nils G., Woodbury, Neal W., & Yan, Hao (2014). Multi-enzyme complexes on DNA scaffolds capable of substrate channelling with an artificial swinging arm. NATURE NANOTECHNOLOGY, 9(7), 531-536. http://dx.doi.org/10.1038/NNANO.2014.100

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