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Contemporary vaccine development relies less on empirical methods of vaccine construction, and now employs a powerful array of precise engineering strategies to construct immunogenic live vaccines. In this review, we

Contemporary vaccine development relies less on empirical methods of vaccine construction, and now employs a powerful array of precise engineering strategies to construct immunogenic live vaccines. In this review, we will survey various engineering techniques used to create attenuated vaccines, with an emphasis on recent advances and insights. We will further explore the adaptation of attenuated strains to create multivalent vaccine platforms for immunization against multiple unrelated pathogens.

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  • 2014-07-31
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    Galen, James E., & Curtiss, Roy, III (2014). The delicate balance in genetically engineering live vaccines. VACCINE, 32(35), 4376-4385. http://dx.doi.org/10.1016/j.vaccine.2013.12.026

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