The cytokine MIF (Macrophage Migration Inhibitory Factor) has diverse physiological roles and is present at elevated concentrations in numerous disease states. However, its molecular heterogeneity has not been previously investigated in biological samples. Mass Spectrometric Immunoassay (MSIA) may help elucidate MIF post-translational modifications existing in vivo and provide additional clarity regarding its relationship to diverse pathologies.
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- Digital object identifier: 10.1186/s12953-014-0052-3
- Identifier TypeInternational standard serial numberIdentifier Value1477-5956
- The electronic version of this article is the complete one and can be found online at: http://www.proteomesci.com/content/12/1/52, opens in a new window
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Sherma, Nisha D., Borges, Chad R., Trenchevska, Olgica, Jarvis, Jason W., Rehder, Douglas S., Oran, Paul E., Nelson, Randall W., & Nedelkov, Dobrin (2014). Mass Spectrometric Immunoassay for the qualitative and quantitative analysis of the cytokine Macrophage Migration Inhibitory Factor (MIF). PROTEOME SCIENCE, 12:52. http://dx.doi.org/10.1186/s12953-014-0052-3