Description

MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene output at the post-transcriptional level by targeting degenerate elements primarily in 3′untranslated regions (3′UTRs) of mRNAs. Individual miRNAs can regulate networks

MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene output at the post-transcriptional level by targeting degenerate elements primarily in 3′untranslated regions (3′UTRs) of mRNAs. Individual miRNAs can regulate networks of hundreds of genes, yet for the majority of miRNAs few, if any, targets are known. Misexpression of miRNAs is also a major contributor to cancer progression, thus there is a critical need to validate miRNA targets in high-throughput to understand miRNAs' contribution to tumorigenesis.

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Date Created
  • 2014-09-29
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  • Text
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    Identifier
    • Digital object identifier: 10.1093/nar/gku626
    • Identifier Type
      International standard serial number
      Identifier Value
      1362-4962
    • Identifier Type
      International standard serial number
      Identifier Value
      0305-1048

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    Wolter, Justin M., Kotagama, Kasuen, Pierre-Bez, Alexandra C., Firago, Mari, & Mangone, Marco (2014). 3 ' LIFE: a functional assay to detect miRNA targets in high-throughput. NUCLEIC ACIDS RESEARCH, 42(17), 0-0. http://nar.oxfordjournals.org.ezproxy1.lib.asu.edu/content/early/2014/0…

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