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Background: Opioid peptides, including dynorphin A, besides their analgesic action in the nervous system, exert a broad spectrum of effects on cells of the immune system, including leukocyte migration, degranulation

Background: Opioid peptides, including dynorphin A, besides their analgesic action in the nervous system, exert a broad spectrum of effects on cells of the immune system, including leukocyte migration, degranulation and cytokine production. The mechanisms whereby opioid peptides induce leukocyte responses are poorly understood. The integrin Mac-1 (alpha(M)beta(2), CD11b/CD18) is a multiligand receptor which mediates numerous reactions of neutrophils and monocyte/macrophages during the immune-inflammatory response.

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    Date Created
    • 2015-06-03
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1186/s12990-015-0027-0
    • Identifier Type
      International standard serial number
      Identifier Value
      1744-8069

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    Podolnikova, Nataly P., Brothwell, Julie A., & Ugarova, Tatiana P. (2015). The opioid peptide dynorphin A induces leukocyte responses via integrin Mac-1 (alpha(M)beta(2), CD11b/CD18). MOLECULAR PAIN, 11. http://dx.doi.org/10.1186/s12990-015-0027-0

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