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Membrane proteins are key players in biological systems, mediating signalling events and the specific transport of e.g. ions and metabolites. Consequently, membrane proteins are targeted by a large number of

Membrane proteins are key players in biological systems, mediating signalling events and the specific transport of e.g. ions and metabolites. Consequently, membrane proteins are targeted by a large number of currently approved drugs. Understanding their functions and molecular mechanisms is greatly dependent on structural information, not least on complexes with functionally or medically important ligands. Structure determination, however, is hampered by the difficulty of obtaining well diffracting, macroscopic crystals.

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    Date Created
    • 2015-07-01
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1107/S2052252515008969
    • Identifier Type
      International standard serial number
      Identifier Value
      2052-2525

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    Bublitz, Maike, Nass, Karol, Drachmann, Nikolaj D., Markvardsen, Anders J., Gutmann, Matthias J., Barends, Thomas R. M., Mattle, Daniel, Shoeman, Robert L., Doak, R. Bruce, Boutet, Sebastien, Messerschmidt, Marc, Seibert, Marvin M., Williams, Garth J., Foucar, Lutz, Reinhard, Linda, Sitsel, Oleg, Gregersen, Jonas L., Clausen, Johannes D., Boesen, Thomas, Gotfryd, Kamil, Wang, Kai-Tuo, Olesen, Claus, Moller, Jesper V., Nissen, Poul, & Schlichting, Ilme (2015). Structural studies of P-type ATPase-ligand complexes using an X-ray free-electron laser. IUCRJ, 2, 409-420. http://dx.doi.org/10.1107/S2052252515008969

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