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Malignant cancers that lead to fatal outcomes for patients may remain dormant for very long periods of time. Although individual mechanisms such as cellular dormancy, angiogenic dormancy and immunosurveillance have

Malignant cancers that lead to fatal outcomes for patients may remain dormant for very long periods of time. Although individual mechanisms such as cellular dormancy, angiogenic dormancy and immunosurveillance have been proposed, a comprehensive understanding of cancer dormancy and the “switch” from a dormant to a proliferative state still needs to be strengthened from both a basic and clinical point of view. Computational modeling enables one to explore a variety of scenarios for possible but realistic microscopic dormancy mechanisms and their predicted outcomes.

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    Date Created
    • 2014-10-16
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  • Text
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    Identifier
    • Digital object identifier: 10.1371/journal.pone.0109934
    • Identifier Type
      International standard serial number
      Identifier Value
      1045-3830
    • Identifier Type
      International standard serial number
      Identifier Value
      1939-1560

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    Chen, D., Jiao, Y., & Torquato, S. (2014). A Cellular Automaton Model for Tumor Dormancy: Emergence of a Proliferative Switch. PLoS ONE, 9(10). doi:10.1371/journal.pone.0109934

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