Description

Improved antigenicity against HIV-1 envelope (Env) protein is needed to elicit vaccine-induced protective immunity in humans. Here we describe the first tests in non-human primates (NHPs) of Env gp140 protein

Improved antigenicity against HIV-1 envelope (Env) protein is needed to elicit vaccine-induced protective immunity in humans. Here we describe the first tests in non-human primates (NHPs) of Env gp140 protein fused to a humanized anti-LOX-1 recombinant antibody for delivering Env directly to LOX-1-bearing antigen presenting cells, especially dendritic cells (DC). LOX-1, or 1ectin-like oxidized low-density lipoprotein (LDL) receptor-1, is expressed on various antigen presenting cells and endothelial cells, and is involved in promoting humoral immune responses.

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Date Created
  • 2016-04-14
Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1371/journal.pone.0153484
    • Identifier Type
      International standard serial number
      Identifier Value
      1045-3830
    • Identifier Type
      International standard serial number
      Identifier Value
      1939-1560

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    Zurawski, G., Zurawski, S., Flamar, A., Richert, L., Wagner, R., Tomaras, G. D., . . . Levy, Y. (2016). Targeting HIV-1 Env gp140 to LOX-1 Elicits Immune Responses in Rhesus Macaques. Plos One, 11(4). doi:10.1371/journal.pone.0153484

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