Proteins can exist as multiple proteoforms in vivo, as a result of alternative splicing and single-nucleotide polymorphisms (SNPs), as well as posttranslational processing. To address their clinical significance in a context of diagnostic information, proteoforms require a more in-depth analysis. Mass spectrometric immunoassays (MSIA) have been devised for studying structural diversity in human proteins. MSIA enables protein profiling in a simple and high-throughput manner, by combining the selectivity of targeted immunoassays, with the specificity of mass spectrometric detection.
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- Digital object identifier: 10.3390/proteomes4010013
- Identifier TypeInternational standard serial numberIdentifier Value2227-7382
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Trenchevska, O., Nelson, R., & Nedelkov, D. (2016). Mass Spectrometric Immunoassays in Characterization of Clinically Significant Proteoforms. Proteomes, 4(1), 13. doi:10.3390/proteomes4010013