A distinct pathovar of Salmonella enterica serovar Typhimurium, ST313, has emerged in sub-Saharan Africa as a major cause of fatal bacteremia in young children and HIV-infected adults. D23580, a multidrug resistant clinical isolate of ST313, was previously shown to have undergone genome reduction in a manner that resembles that of the more human-restricted pathogen, Salmonella enterica serovar Typhi. It has since been shown through tissue distribution studies that D23580 is able to establish an invasive infection in chickens.
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- Yang, Jiseon (Contributor)
- Barrila, Jennifer (Contributor)
- Roland, Kenneth (Contributor)
- Kilbourne, Jacquelyn (Contributor)
- Ott, C. Mark (Author)
- Forsyth, Rebecca (Contributor)
- Nickerson, Cheryl (Contributor)
- Immunotherapy, Vaccines and Virotherapy (Contributor)
- Biodesign Institute (Contributor)
- 2015-06-19
- Digital object identifier: 10.1371/journal.pntd.0003839
- Identifier TypeInternational standard serial numberIdentifier Value1935-2727
- Identifier TypeInternational standard serial numberIdentifier Value1935-2735
- The article is published at http://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0003839, opens in a new window
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Yang, J., Barrila, J., Roland, K. L., Kilbourne, J., Ott, C. M., Forsyth, R. J., & Nickerson, C. A. (2015). Characterization of the Invasive, Multidrug Resistant Non-typhoidal Salmonella Strain D23580 in a Murine Model of Infection. PLOS Neglected Tropical Diseases, 9(6). doi:10.1371/journal.pntd.0003839