Description

The diverse, specialized genes present in today’s lifeforms evolved from a common core of ancient, elementary genes. However, these genes did not evolve individually: gene expression is controlled by a

The diverse, specialized genes present in today’s lifeforms evolved from a common core of ancient, elementary genes. However, these genes did not evolve individually: gene expression is controlled by a complex network of interactions, and alterations in one gene may drive reciprocal changes in its proteins’ binding partners. Like many complex networks, these gene regulatory networks (GRNs) are composed of communities, or clusters of genes with relatively high connectivity.

Reuse Permissions
  • application/pdf

    Download count: 0

    Details

    Contributors
    Date Created
    • 2016-06-30
    Resource Type
  • Text
  • Collections this item is in
    Identifier
    • Digital object identifier: 10.1371/journal.pcbi.1005009
    • Identifier Type
      International standard serial number
      Identifier Value
      1553-734X
    • Identifier Type
      International standard serial number
      Identifier Value
      1553-7358

    Citation and reuse

    Cite this item

    This is a suggested citation. Consult the appropriate style guide for specific citation guidelines.

    Szedlak, A., Smith, N., Liu, L., Paternostro, G., & Piermarocchi, C. (2016). Evolutionary and Topological Properties of Genes and Community Structures in Human Gene Regulatory Networks. PLOS Computational Biology, 12(6). doi:10.1371/journal.pcbi.1005009

    Machine-readable links