Description
The diverse, specialized genes present in today’s lifeforms evolved from a common core of ancient, elementary genes. However, these genes did not evolve individually: gene expression is controlled by a complex network of interactions, and alterations in one gene may drive reciprocal changes in its proteins’ binding partners.
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Contributors
- Szedlak, Anthony (Author)
- Smith, Nicholas (Author)
- Liu, Li (Author)
- Paternostro, Giovanni (Author)
- Piermarocchi, Carlo (Author)
- College of Health Solutions (Contributor)
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2016-06-30
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Identifier
- Digital object identifier: 10.1371/journal.pcbi.1005009
- Identifier TypeInternational standard serial numberIdentifier Value1553-734X
- Identifier TypeInternational standard serial numberIdentifier Value1553-7358
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- The article is published at http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1005009, opens in a new window
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Szedlak, A., Smith, N., Liu, L., Paternostro, G., & Piermarocchi, C. (2016). Evolutionary and Topological Properties of Genes and Community Structures in Human Gene Regulatory Networks. PLOS Computational Biology, 12(6). doi:10.1371/journal.pcbi.1005009