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The extensive distribution and simultaneous termination of seizures across cortical areas has led to the hypothesis that seizures are caused by large-scale coordinated networks spanning these areas. This view, however,

The extensive distribution and simultaneous termination of seizures across cortical areas has led to the hypothesis that seizures are caused by large-scale coordinated networks spanning these areas. This view, however, is difficult to reconcile with most proposed mechanisms of seizure spread and termination, which operate on a cellular scale. We hypothesize that seizures evolve into self-organized structures wherein a small seizing territory projects high-intensity electrical signals over a broad cortical area.

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    Date Created
    • 2016-03-29
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    Identifier
    • Digital object identifier: 10.1038/ncomms11098
    • Identifier Type
      International standard serial number
      Identifier Value
      2041-1723
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    Smith, E. H., Liou, J., Davis, T. S., Merricks, E. M., Kellis, S. S., Weiss, S. A., . . . Schevon, C. A. (2016). The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures. Nature Communications, 7, 11098. doi:10.1038/ncomms11098

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