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The extensive distribution and simultaneous termination of seizures across cortical areas has led to the hypothesis that seizures are caused by large-scale coordinated networks spanning these areas. This view, however, is difficult to reconcile with most proposed mechanisms of seizure spread and termination, which operate on a cellular scale.

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    Date Created
    2016-03-29
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1038/ncomms11098
    • Identifier Type
      International standard serial number
      Identifier Value
      2041-1723
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    Smith, E. H., Liou, J., Davis, T. S., Merricks, E. M., Kellis, S. S., Weiss, S. A., . . . Schevon, C. A. (2016). The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures. Nature Communications, 7, 11098. doi:10.1038/ncomms11098

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