The extensive distribution and simultaneous termination of seizures across cortical areas has led to the hypothesis that seizures are caused by large-scale coordinated networks spanning these areas. This view, however, is difficult to reconcile with most proposed mechanisms of seizure spread and termination, which operate on a cellular scale.
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- Smith, Elliot H. (Author)
- Liou, Jyun-you (Author)
- Davis, Tyler S. (Author)
- Merricks, Edward M. (Author)
- Kellis, Spencer S. (Author)
- Weiss, Shennan A. (Author)
- Greger, Bradley (Author)
- House, Paul A. (Author)
- McKhann, Guy M. (Author)
- Goodman, Robert R. (Author)
- Emerson, Ronald G. (Author)
- Bateman, Lisa M. (Author)
- Trevelyan, Andrew J. (Author)
- Schevon, Catherine A. (Author)
- Ira A. Fulton Schools of Engineering (Contributor)
- Digital object identifier: 10.1038/ncomms11098
- Identifier TypeInternational standard serial numberIdentifier Value2041-1723
- The final version of this article, as published in Nature Communications, can be viewed online at: https://www.nature.com/articles/ncomms11098, opens in a new window
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Smith, E. H., Liou, J., Davis, T. S., Merricks, E. M., Kellis, S. S., Weiss, S. A., . . . Schevon, C. A. (2016). The ictal wavefront is the spatiotemporal source of discharges during spontaneous human seizures. Nature Communications, 7, 11098. doi:10.1038/ncomms11098