Chronic manganese (Mn) exposure is associated with neuromotor and neurocognitive deficits, but the exact mechanism of Mn neurotoxicity is still unclear. With the advent of magnetic resonance imaging (MRI), in-vivo analysis of brain structures has become possible. Among different sub-cortical structures, the basal ganglia (BG) has been investigated as a putative anatomical biomarker in MR-based studies of Mn toxicity. However, previous investigations have yielded inconsistent results in terms of regional MR signal intensity changes.
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- Lao, Yi (Author)
- Dion, Laurie-Anne (Author)
- Gilbert, Guillaume (Author)
- Bouchard, Maryse F. (Author)
- Rocha, Gabriel (Author)
- Wang, Yalin (Contributor)
- Lepore, Natasha (Author)
- Saint-Amour, Dave (Author)
- Ira A. Fulton Schools of Engineering (Contributor)
- 2017-02-03
- Digital object identifier: 10.1038/srep41804
- Identifier TypeInternational standard serial numberIdentifier Value2045-2322
- The final version of this article, as published in Scientific Reports, can be viewed online at: https://www.nature.com/articles/srep41804, opens in a new window
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Lao, Y., Dion, L., Gilbert, G., Bouchard, M. F., Rocha, G., Wang, Y., . . . Saint-Amour, D. (2017). Mapping the basal ganglia alterations in children chronically exposed to manganese. Scientific Reports, 7, 41804. doi:10.1038/srep41804