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LL-37, a cationic antimicrobial peptide, has numerous immune-modulating effects. However, the identity of a receptor that mediates the responses in immune cells remains uncertain. We have recently demonstrated that LL-37

LL-37, a cationic antimicrobial peptide, has numerous immune-modulating effects. However, the identity of a receptor that mediates the responses in immune cells remains uncertain. We have recently demonstrated that LL-37 interacts with the αMI-domain of integrin α[subscript M]β[subscript 2] (Mac-1), a major receptor on the surface of myeloid cells, and induces a migratory response in Mac-1-expressing monocyte/macrophages as well as activation of Mac-1 on neutrophils.

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    Date Created
    • 2016-07-07
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    Identifier
    • Digital object identifier: 10.2147/RRBC.S107070
    • Identifier Type
      International standard serial number
      Identifier Value
      2230-3154
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    Ugarova, T., Moreno, B., Podolnikova, N., & Lishko, V. (2016). Identification of human cathelicidin peptide LL-37 as a ligand for macrophage integrin aMb2 (Mac-1, CD11b/CD18) that promotes phagocytosis by opsonizing bacteria. Research and Reports in Biochemistry, Volume 6, 39-55. doi:10.2147/rrbc.s107070

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