Description

Primary biliary cirrhosis (PBC) is a chronic progressive liver disease that often leads to fibrosis, cirrhosis, and end-stage liver disease. The diagnosis is made when there is evidence of cholestasis

Primary biliary cirrhosis (PBC) is a chronic progressive liver disease that often leads to fibrosis, cirrhosis, and end-stage liver disease. The diagnosis is made when there is evidence of cholestasis and reactivity to the antimitochondrial antibody. The etiology of PBC is poorly understood; however, several lines of evidence suggest an environmental factor that triggers a series of immune-mediated inflammatory reactions in the bile ducts in a genetically susceptible individual.

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    Date Created
    • 2015-09-10
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.2147/ODRR.S69477
    • Identifier Type
      International standard serial number
      Identifier Value
      2230-6161
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    Lindor, K., Ali, A., & Byrne, T. (2015). Orphan drugs in development for primary biliary cirrhosis: challenges and progress. Orphan Drugs: Research and Reviews, 83. doi:10.2147/odrr.s69477

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