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The brain is a common site of metastatic disease in patients with breast cancer, which has few therapeutic options and dismal outcomes. The purpose of our study was to identify

The brain is a common site of metastatic disease in patients with breast cancer, which has few therapeutic options and dismal outcomes. The purpose of our study was to identify common and rare events that underlie breast cancer brain metastasis. We performed deep genomic profiling, which integrated gene copy number, gene expression and DNA methylation datasets on a collection of breast brain metastases. We identified frequent large chromosomal gains in 1q, 5p, 8q, 11q, and 20q and frequent broad-level deletions involving 8p, 17p, 21p and Xq.

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    Date Created
    • 2014-01-29
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.1371/journal.pone.0085448
    • Identifier Type
      International standard serial number
      Identifier Value
      1045-3830
    • Identifier Type
      International standard serial number
      Identifier Value
      1939-1560

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    Salhia, B., Kiefer, J., Ross, J. T., Metapally, R., Martinez, R. A., Johnson, K. N., . . . Tran, N. L. (2014). Integrated Genomic and Epigenomic Analysis of Breast Cancer Brain Metastasis. PLoS ONE, 9(1). doi:10.1371/journal.pone.0085448

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