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Chromatin proteins have expanded the mammalian synthetic biology toolbox by enabling control of active and silenced states at endogenous genes. Others have reported synthetic proteins that bind DNA and regulate

Chromatin proteins have expanded the mammalian synthetic biology toolbox by enabling control of active and silenced states at endogenous genes. Others have reported synthetic proteins that bind DNA and regulate genes by altering chromatin marks, such as histone modifications. Previously, we reported the first synthetic transcriptional activator, the “Polycomb-based transcription factor” (PcTF) that reads histone modifications through a protein–protein interaction between the polycomb chromodomain motif and trimethylated lysine 27 of histone H3 (H3K27me3).

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    Date Created
    • 2017-01-09
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  • Text
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    • Digital object identifier: 10.1038/s41525-016-0002-3
    • Identifier Type
      International standard serial number
      Identifier Value
      2056-7944
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    Nyer, D. B., Daer, R. M., Vargas, D., Hom, C., & Haynes, K. A. (2017). Regulation of cancer epigenomes with a histone-binding synthetic transcription factor. Npj Genomic Medicine, 2(1). doi:10.1038/s41525-016-0002-3

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