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Cerebral small-vessel damage manifests as white matter hyperintensities and cerebral atrophy on brain MRI and is associated with aging, cognitive decline and dementia. We sought to examine the interrelationship of

Cerebral small-vessel damage manifests as white matter hyperintensities and cerebral atrophy on brain MRI and is associated with aging, cognitive decline and dementia. We sought to examine the interrelationship of these imaging biomarkers and the influence of hypertension in older individuals. We used a multivariate spatial covariance neuroimaging technique to localize the effects of white matter lesion load on regional gray matter volume and assessed the role of blood pressure control, age and education on this relationship.

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    Date Created
    • 2017-05-15
    Resource Type
  • Text
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    Identifier
    • Digital object identifier: 10.3389/fnagi.2017.00132
    • Identifier Type
      International standard serial number
      Identifier Value
      1663-4365

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    Kern, K. C., Wright, C. B., Bergfield, K. L., Fitzhugh, M. C., Chen, K., Moeller, J. R., . . . Alexander, G. E. (2017). Blood Pressure Control in Aging Predicts Cerebral Atrophy Related to Small-Vessel White Matter Lesions. Frontiers in Aging Neuroscience, 9. doi:10.3389/fnagi.2017.00132

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