Quantitative three-dimensional (3D) computed tomography (CT) imaging of living single cells enables orientation-independent morphometric analysis of the intricacies of cellular physiology. Since its invention, x-ray CT has become indispensable in the clinic for diagnostic and prognostic purposes due to its quantitative absorption-based imaging in true 3D that allows objects of interest to be viewed and measured from any orientation. However, x-ray CT has not been useful at the level of single cells because there is insufficient contrast to form an image.
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- Digital object identifier: 10.1126/sciadv.1602580
- Identifier TypeInternational standard serial numberIdentifier Value2375-2548
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Kelbauskas, L., Shetty, R., Cao, B., Wang, K., Smith, D., Wang, H., . . . Meldrum, D. R. (2017). Optical computed tomography for spatially isotropic four-dimensional imaging of live single cells. Science Advances, 3(12). doi:10.1126/sciadv.1602580