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- Creators: Marine Biological Laboratory Archives
Description
Optical Communications are at a high point of interest by the space engineering community. After successful projects like the Lunar Laser Communications Demonstration (LLCD), NASA has become interested in augmenting their current Deep Space Network (DSN) with optical communication links. One such link is Deep Space Optical Communications (DSOC) which will be launching with the Psyche mission. To gain a full understanding of the advantages of this network, this thesis will go over the history and benefits of optical communications both on Earth and in space. This thesis will then go in depth on NASAs DSOC project through an algorithmic implementation of the communications channel.
ContributorsHorton, Paul Alexander (Author) / Mauskopf, Philip (Thesis director) / Sandy, Douglas (Committee member) / Martin, Thomas (Committee member) / Software Engineering (Contributor) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
The human hairless gene (HR) encodes a 130 kDa transcription factor that is primarily expressed in the brain and skin. In the promoter and 5'-untranslated regions (5'-UTR) of HR, there are three putative consensus p53 responsive elements (p53RE). p53 is a tumor suppressor protein that regulates cell proliferation, apoptosis, and other cell functions. The p53 protein, a known tumor suppressor, acts as a transcription factor and binds to DNA p53REs to activate or repress transcription of the target gene. In general, the p53 binding sequence is 5'-RRRCWWGYYY-3' where W is A or T, and R and Y are purines or pyrimidines, respectively. However, even if the p53 binding sequence does not match the consensus sequence, p53 protein might still be able to bind to the response element. The intent of this investigation was to identify and characterize the p53REs in the promoter and 5'-UTR of HR. If the three p53REs (p53RE1, p53RE2, and p53RE3) are functional, then p53 can bind there and might regulate HR gene expression. The first aim for this thesis was to clone the putative p53REs into a luciferase reporter and to characterize the transcription of these p53REs in glioblastoma (U87 MG) and human embryonic kidney (HEK293) cell lines. Through the transactivation assay, it was discovered that p53REs 2 and 3 were functional in HEK293, but none of the response elements were functional in U87 MG. Since p53 displayed a different regulatory capacity of HR expression in HEK293 and U87 MG cells, the second aim was to verify whether the p53REs are mutated in GBM U87 MG cells by genomic DNA sequencing.
ContributorsMaatough, Anas (Author) / Neisewander, Janet (Thesis director) / Hsieh, Jui-Cheng (Committee member) / Goldstein, Elliott (Committee member) / School of Life Sciences (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
Glioblastoma multiforme is associated with a very low survival rate and is recognized as the most vicious form of intracranial cancer. The Akt gene pathway has three different isoforms, each of which has a different role in the tumors of GBM. Preliminary data suggests that Akt3 may work to decrease tumorigenicity. A produced image that visualizes the subcellular localization of Akt3 led the author to believe that Akt3 may reduce tumorigenicity by decreasing genomic instability caused by the cancer. To explore this, flow cytometry was performed on GBM cell lines with Akt3v1 over-expression, Akt3v2 over-expression, and a control glioma cell line.
ContributorsGhorayeb, Antoine (Author) / Neisewander, Janet (Thesis director) / Diehnelt, Chris (Committee member) / Moussallem, Suzan (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2012-12
Description
This project, Building the Backdrop, Expanding Perspectives on Sustainability, is a sculpture of a desert sunset that seeks to explore important sustainability issues and highlight the beauty in sustainable practices. Constructed for an honors thesis project at Arizona State University, the primary medium used was cardboard repurposed from package deliveries to bring attention to modern overconsumption of packaging materials and showcase our ability to give new life to traditionally single use materials. I invite you to interact with the piece by sharing photos of yourself in front of it to help spread its message and exploring the resources shared along with the sculpture.
ContributorsSandoval, Nicole (Author) / Hines, Taylor (Thesis director) / Meissinger, Ellen (Committee member) / Barrett, The Honors College (Contributor) / Department of Supply Chain Management (Contributor) / Dean, W.P. Carey School of Business (Contributor) / College of Integrative Sciences and Arts (Contributor)
Created2024-05
Description
A guidebook meant to be used by the leadership of the club Poly Purrs. It includes definitions of key terms as well as literature-backed discussion of free-roaming cats in general. The second half of it is advice and information drawn from my own experience with the cat population on the Polytechnic campus.
ContributorsWiese, Alexa (Author) / Murphree, Julie (Thesis director) / Gallaway, Cynthia (Committee member) / Barrett, The Honors College (Contributor) / College of Integrative Sciences and Arts (Contributor)
Created2024-05
ContributorsMarine Biological Laboratory Archives (Publisher) / Arizona Board of Regents (Publisher)
Created1979-09-11 to 1979-09-13
Description
We discuss the intricate and puzzling concept of quantum entanglement, and not only
define it but also consider the implications of the behaviors of entangled particles. The ability of
these particles to provide instantaneous information about their entangled counterparts sparked a debate among physicists as to whether or not these particles had definite quantities before
measurement, and whether or not their behaviors could be explained by a local hidden-variables
theorem. Mermin’s gedanken demonstration for a two-particle entangled system is introduced, as well as Bell’s inequality, and an explanation of how a pair of two entangled particles violate this inequality. Additionally, we also discuss various experimental verifications that were able to use Bell’s inequality to verify the expected quantum mechanical results for their entangled systems.
ContributorsDavis, Elsie (Author) / Foy, Joseph (Thesis director) / Hines, Taylor (Committee member) / Barrett, The Honors College (Contributor) / College of Integrative Sciences and Arts (Contributor)
Created2024-05
Description
Terrestrial hermit crabs serve an incredibly important ecological role in seed dispersal and as decomposers along coastal shorelines. They have also become quite popular in the commercial pet trade, with one species, Coenobita clypeatus, being particularly favored. Typically, these hermit crabs are easily captured and removed from the wild with little protection in their native ranges. In Hermitage Bay, Tobago, there is little information about the population numbers, composition, shell preference, and substrate preference of C. clypeatus in their native habitat. In this study, we estimated population size, gastropod shell preferences, and substrate preference conditions when clustering. We conducted mark re-capture surveys in March, July, and December 2023 and collected morphological data from captured hermit crabs. Our results indicate that the estimated population was highest in July, with the variation being significant when using the Schnabel mark re-capture estimation formula. The most common overall shell type, Columbella mercatoria (West Indian Dove Shell), was prevalent among the smaller sized, younger hermit crabs; while the larger hermit crabs preferred Cittarium pica (West Indian Top Shell). The most preferred substrate for these terrestrial hermit crabs were areas with a mixture of sand and dirt, with high amounts of vegetation and leaf waste and low amounts of human litter. These results suggest a predominantly young population and that beach cleanups should focus on removing human litter entirely, while leaving leaf waste and other fallen logs and branches and not using the collected decomposing plant matter for bonfires. This can help maintain a healthy hermit crab population that continues to benefit the coastlines in Tobago as well as other ecosystems.
ContributorsLindteigen, Amy (Author) / Briggs, Georgette (Thesis director) / Mohammed, Ryan (Committee member) / Barrett, The Honors College (Contributor) / College of Integrative Sciences and Arts (Contributor) / Dean, W.P. Carey School of Business (Contributor)
Created2024-05
Description
Chisholm’s contrary-to-duty paradox raises important questions for formulating instances of conditional obligation. Angelika Kratzer is one linguist whose theories offer some solutions to these questions; more generally, she provides theories for how we should represent modals, conditionals, and other features of language in terms of functions. Though her theories are incredibly useful, they do not adequately represent the Chisholm scenario as a whole. In this paper, I attempt to address this shortcoming in her theory. First, I present and explain some of Kratzer’s main ideas. Then, I explain how her theory offers a solution to Chisholm’s Paradox, and examine a shortcoming of her theory as presented– specifically, the fact that her theory does not account for the importance of different norms in relation to each other. Finally, with the Chisholm situation as a backdrop, I offer my own contribution to her theory. Namely, I propose assigning an importance “score” to each norm, and factoring that “score” into the machinery of Kratzer’s theory.
ContributorsBrooks, Elizabeth (Author) / nair, shyam (Thesis director) / Pinillos, Angel (Committee member) / Barrett, The Honors College (Contributor) / College of Integrative Sciences and Arts (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor)
Created2024-05
Description
Immediate early genes (IEGs) are the first set of genes to be transcribed in a cell in response to stimuli; their expression is quick and is not protein synthesis dependent. Neurons are activated in response to external stimuli, causing a rapid increase in IEG expression in the brain. IEG proteins go on to affect fundamental neurobiological processes that are known to be dysfunctional in patients with psychiatric disorders, and therefore IEGs have been connected to the pathogenesis of schizophrenia. Early growth response (Egr) genes are immediate early gene transcription factors (IEG-TFs) that are expressed in response to an altered environment. The IEG-TFs, early growth response 1 (EGR1) and early growth response 3 (EGR3) are necessary for processes such as memory and synaptic plasticity; lack of function in these genes causes dysfunction or disruption of these processes. We wanted to observe if increasing the function of Egrs by overexpressing them will lead to improved memory. To help further understand how behavior is affected by the overexpression (O/E) of Egr1 in response to stimuli, the AAV-ESARE-Egr1 virus was developed to be injected in the hippocampus of mice. In the hippocampus of wild-type (WT) mice, cells that are active endogenously express Egr1. The virus was created using the synaptic activity-response element (SARE), an element discovered on the promoter of the IEG activity-regulated cytoskeleton-associated (Arc) gene by our collaborators in Japan. Using an “enhanced” form of SARE (ESARE), our newly created virus acts to overexpress Egr1 only in response to activity in the hippocampus; we can then observe if the behavioral processes associated with Egr1 will improve. First, this project aims to validate that the AAV-ESARE-Egr1 virus is increasing Egr1 expression in the active hippocampal dentate gyrus (DG) granule cells of WT mice, and only in response to activity. The activity is in the form of a physiological stimulus, environmental enrichment (EE) and a non-physiological stimulus, electroconvulsive seizures (ECS). After confirming these characteristics of AAV-ESARE-Egr1 we can then use it to observe if EGR1 O/E improves the memory of mice.
ContributorsWallace, Sophie (Author) / Lewis, Candace (Thesis director) / Gallitano, Amelia (Committee member) / Barrett, The Honors College (Contributor) / College of Integrative Sciences and Arts (Contributor)
Created2024-05