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- Creators: Barrett, The Honors College
Description
Those that must follow a Celiac diet should know that there are challenges that come with it. Wheat contains a ton of essential vitamins and minerals such as folate, magnesium, thiamin and niacin among many others. By cutting these out, it is possible to become deficient in these essential nutrients that play roles all throughout the body. One of our goals in making this cookbook was to include recipes that would be packed with these dietary components. We wanted to not only make this cookbook tangible for newly-diagnosed Celiac people, but also ensure that they have the balanced diet they need to avoid deficiencies. While admittedly not every meal is going to be loaded with those good vitamins and minerals, we believe the phrase “everything in moderation” is a good way to approach this new diet.
ContributorsMoir, Carmen Juel (Co-author) / Horner, Hannah (Co-author) / Johnston, Carol (Thesis director) / Grgich, Traci (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
This paper intends to parse out the differences between various types of nationalism. It will break down the current trend toward xenophobic rhetoric in modern democratic election campaigns. Then, it will discuss the effect of modern media coverage in the dissemination and sustenance of toxic nationalist rhetoric and cover the role of President Donald J. Trump in doing the same. Finally, it will outline what appears to be the root cause of this current uptick in toxic nationalism and recommend some methods by which the issue can be resolved in the current political atmosphere.
ContributorsMcCreary, Micah (Author) / Goggin, Maureen (Thesis director) / Chanley, Jesse (Committee member) / School of International Letters and Cultures (Contributor) / Department of English (Contributor) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Rexinoids such as Bexarotene have been developed as effective treatments of different diseases including lymphoma, breast cancer, lung cancer, Alzheimer’s disease, and diabetes. This is due to the widespread nature of the retinoid X receptor, which is the target of these drugs, throughout the body. However, Bexarotene is not infallible and has many negative side effects which limit the use of the drug to only a short period of time. This may be fine for chemotherapy, but rexinoids have been proposed to also be effective at preventing cancer as well. This is not currently possible with the side effects seen with approved rexinoids. Due to this, six novel rexinoids were created in hopes of reducing the side effect profile of rexinoids. The idea of dual agonism was also explored with two of the compounds created as well. All six of these compounds, after creation and purification, were sent off for in vitro and in vivo testing to confirm side effect profile and efficacy.
ContributorsFrazier, Madison S (Author) / Wagner, Carl (Thesis director) / Marshall, Pamela (Committee member) / School of Mathematical and Natural Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Programmed cell death plays an important role in a variety of processes that promote the survival of the host organism. Necroptosis, a form of programmed cell death, occurs through a signaling pathway involving the protein kinase RIPK3. In response to vaccinia virus infection, necroptosis acts through RIPK3 and the adaptor protein DAI to inhibit further viral replication in host cells. Stress granules are accumulations of mRNAs that have stalled in translation due to cellular stress. The toxin arsenite is a canonical inducer of stress granule formation and can cause necroptosis. By initiating necroptosis with arsenite and vaccinia virus, this research project investigated the roles of necroptosis proteins and their localizations into stress granules. The two aims of this research project were to determine if stress granules are important for arsenite-induced necroptosis, and whether the proteins DAI, RIPK3, MLKL, and G3BP localize into stress granules. The first aim was investigated by establishing a DAI and RIPK3 expression system in U2OS cells; arsenite was then used to treat the U2OS cells as well as U2OSΔG3BP cells, which are not able to form stress granules. The second aim was carried out by designing fluorescent tagging for the necroptosis proteins in order to visualize protein localization with fluorescent microscopy. The results showed that arsenite induces DAI-dependent necroptosis in U2OS cells and that this arsenite-induced necroptosis requires stress granules. In addition, it was determined that vaccinia virus induces DAI-dependent necroptosis that also requires stress granules. This project contributes to a greater understanding of the roles of DAI and RIPK3 in necroptosis, as well as the roles of stress granules in necroptosis, both of which are important in research regarding viral infection and cellular stress.
ContributorsGogerty, Carolina (Author) / Jacobs, Bertram (Thesis director) / Langland, Jeffrey (Committee member) / Jentarra, Garilyn (Committee member) / School of Life Sciences (Contributor, Contributor) / School of Music (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
This paper investigates whether incarceration has an effect on political orientation, addressing the hypothesis that the experience of incarceration also shapes the political behavior and attitudes of those who have been confined (Manza, Uggen 2006; Clear 2007; Travis 2005). The primary aim of the research is to identify what role, if at all, the penal system plays in how incarcerated individuals think about politics. The data relied on to reach conclusions about the incarcerated population derives from voluntary responses to a survey implemented within a company that hires formerly and currently incarcerated persons. I find that the majority of the sample I surveyed became more politically liberal as a result of incarceration and a vast majority want to participate in the political process. These findings corroborate my hypotheses regarding the effects of incarceration on political beliefs, but contradict my assumption regarding the effect of social capital on their desire to participate in politics.
ContributorsFrederickson, Nicola B (Author) / Rigoni, Adam (Thesis director) / Forst, Bradley (Committee member) / Dean, W.P. Carey School of Business (Contributor) / School of Politics and Global Studies (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Employee loyalty and commitment have potential to benefit an organization. However, what happens when limits are pushed and levels of loyalty and commitment are built on the wrong foundations? Here, a deductive theory surrounding the process through which The Walt Disney Company builds “over-commitment” and loyalty is presented. Personal experience as a Disney employee, combined with review of literary sources, allows for the analysis of impact surrounding three types of organizational commitment (continuance, normative, and affective) in The Walt Disney Company. The inner-workings of the company’s processes to “brainwash” employees are displayed through fear tactics, encouraging gratitude in new employees, assigning the phrase “Cast Member” to all employees, relying on influential exposure to the brand early in the individual’s life, and employees’ deep connection with the company itself. The effects of withdrawal and “over-commitment” for employees is also analyzed and enclosed.
ContributorsGagliano, Raina Elyse (Author) / Baer, Michael (Thesis director) / Bonfiglio, Thomas (Committee member) / Department of Management and Entrepreneurship (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Genistein, a compound found in soy that functions as a phytoestrogen, has been found to play a role in the body’s inflammatory response. By suppressing the expression of inflammatory genes and inhibiting tumor cell growth, genistein is thought to have both anti-inflammatory and cancer fighting properties. This study seeks to demonstrate genistein’s potential to mitigate the negative consequences of consuming a high fat diet specifically as it relates to increased inflammation and changes in the gut microbiome. Using an animal model, the study tested whether supplementing the mice’s diet with soy derived genistein would affect their serum IL-6 levels and the way in which their gut microbiomes responded to their high fat consumption. It was presumed that genistein supplementation would result in a less significant shift from the biomarkers tested in the control group and reduce the impact of the high fat diet. It was also hypothesized that consumption of the high fat diet would raise IL-6 levels and increase the presence of harmful bacteria in the test subjects.
ContributorsPettit, Gabrielle Sofia (Author) / Whisner, Dr. Corrie (Thesis director) / Al-Nakkash, Dr. Layla (Committee member) / Ortega Santos, Carmen (Committee member) / Dean, W.P. Carey School of Business (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Sports have always incited an emotional response in fans unlike anything else and creates a special relationship between fans and their favorite sports team. However, in the current age, attendance numbers have started to fall, due to games being available on multiple platforms for viewers to watch in their own homes, along with the increased competition in the entertainment industry. Teams are seeking new ways to leverage that relationship with their fans in order to draw fans into their games. This study will look at the history of fandom and reasons why people remain loyal to “their team” year after year. In turn, fan loyalty and increased attendance translates to increased revenue for teams across all sports. As part of this study, existing literature was reviewed covering the following areas of fandom: fan loyalty, memory association, and team actions that will impact fans. This research will aid in developing hypotheses to test on why fans remain fans and how their fan dedication develops. A questionnaire was then developed to find the reason why a fan is so dedicated to their favorite team. Respondents are asked to self- identify as a fan type in order to quantify the label of “fan” and build a deeper analysis within the questions being asked. The three fan options are diehard, casual and social fans. The following analysis explored why people are fans and what factors influence their level of fan loyalty. From that, recommendations were developed for professional sports teams to take advantage of the factors found in the analysis. The hope is that they will be able to translate psychological factors and an emotional connection into a concrete strategy to drive ticket sales and revenue.
ContributorsTassinari, Isabella (Author) / McIntosh, Daniel (Thesis director) / Eaton, John (Committee member) / Department of Information Systems (Contributor) / Dean, W.P. Carey School of Business (Contributor) / Department of Marketing (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
This study sought to replicate previous work in student conceptions of formal proofs based on informal arguments, originally explored by Zazkis et al. (2016). Additional tasks were added to the experiment to produce new data that could further verify the analysis of Zazkis et al. (2016) as well as provide more insight into how students comprehend proofs, what types of mistakes occur, and why. Results from one-on-one interviews confirmed that some students were not able to make accurate informal to formal comparisons because they were not considering multiple facets of the problem. Additionally, patterns in the students’ analysis introduced more questions concerning the motivations behind what students choose to think about when they read and dissect proofs.
ContributorsPeng, Tina (Author) / Zazkis, Dov (Thesis director) / Roh, Kyeong Hah (Committee member) / School of Mathematical and Statistical Sciences (Contributor, Contributor) / Computer Science and Engineering Program (Contributor) / Computing and Informatics Program (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Medicine is evolving at an accelerating rate. The needs of the future in medicine are different than the needs of today. With many possible outcomes for the future of medicine, researchers and physicians have tried to predict the future for particular fields. As new healthcare workers enter the medical field, their training must be tailored to provide the best education to prepare healthcare workers for their careers. Therefore, it is imperative to take a closer look into the future in order to better decide how to train doctors, nurses, PA’s, etc. effectively to provide the best care possible.
ContributorsHewlett, Jessica Lynn (Author) / Sklar, David (Thesis director) / Lindor, Keith (Committee member) / College of Health Solutions (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05