Matching Items (383)
Description
Breast cancer is the leading cause of cancer-related deaths of women in the united states. Traditionally, Breast cancer is predominantly treated by a combination of surgery, chemotherapy, and radiation therapy. However, due to the significant negative side effects associated with these traditional treatments, there has been substantial efforts to develop alternative therapies to treat cancer. One such alternative therapy is a peptide-based therapeutic cancer vaccine. Therapeutic cancer vaccines enhance an individual's immune response to a specific tumor. They are capable of doing this through artificial activation of tumor specific CTLs (Cytotoxic T Lymphocytes). However, in order to artificially activate tumor specific CTLs, a patient must be treated with immunogenic epitopes derived from their specific cancer type. We have identified that the tumor associated antigen, TPD52, is an ideal target for a therapeutic cancer vaccine. This designation was due to the overexpression of TPD52 in a variety of different cancer types. In order to start the development of a therapeutic cancer vaccine for TPD52-related cancers, we have devised a two-step strategy. First, we plan to create a list of potential TPD52 epitopes by using epitope binding and processing prediction tools. Second, we plan to attempt to experimentally identify MHC class I TPD52 epitopes in vitro. We identified 942 potential 9 and 10 amino acid epitopes for the HLAs A1, A2, A3, A11, A24, B07, B27, B35, B44. These epitopes were predicted by using a combination of 3 binding prediction tools and 2 processing prediction tools. From these 942 potential epitopes, we selected the top 50 epitopes ranked by a combination of binding and processing scores. Due to the promiscuity of some predicted epitopes for multiple HLAs, we ordered 38 synthetic epitopes from the list of the top 50 epitope. We also performed a frequency analysis of the TPD52 protein sequence and identified 3 high volume regions of high epitope production. After the epitope predictions were completed, we proceeded to attempt to experimentally detected presented TPD52 epitopes. First, we successful transduced parental K562 cells with TPD52. After transduction, we started the optimization process for the immunoprecipitation protocol. The optimization of the immunoprecipitation protocol proved to be more difficult than originally believed and was the main reason that we were unable to progress past the transduction of the parental cells. However, we believe that we have identified the issues and will be able to complete the experiment in the coming months.
ContributorsWilson, Eric Andrew (Author) / Anderson, Karen (Thesis director) / Borges, Chad (Committee member) / School of Molecular Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2016-05
Description
Visual perceptual learning (VPL) is defined as visual performance improvement after visual experiences. VPL is often highly specific for a visual feature presented during training. Such specificity is observed in behavioral tuning function changes with the highest improvement centered on the trained feature and was originally thought to be evidence for changes in the early visual system associated with VPL. However, results of neurophysiological studies have been highly controversial concerning whether the plasticity underlying VPL occurs within the visual cortex. The controversy may be partially due to the lack of observation of neural tuning function changes in multiple visual areas in association with VPL. Here using human subjects we systematically compared behavioral tuning function changes after global motion detection training with decoded tuning function changes for 8 visual areas using pattern classification analysis on functional magnetic resonance imaging (fMRI) signals. We found that the behavioral tuning function changes were extremely highly correlated to decoded tuning function changes only in V3A, which is known to be highly responsive to global motion with human subjects. We conclude that VPL of a global motion detection task involves plasticity in a specific visual cortical area.
ContributorsShibata, Kazuhisa (Author) / Chang, Li-Hung (Author) / Kim, Dongho (Author) / Nanez, Jose (Author) / Kamitani, Yukiyasu (Author) / Watanabe, Takeo (Author) / Sasaki, Yuka (Author) / New College of Interdisciplinary Arts and Sciences (Contributor)
Created2012-08-28
Description
The Tale of the Tigers is a children’s picture book in which a tiger named Guava is transported from his world of Serenia to our world. In an attempt to find someone to help him with this situation, Guava meets another tiger named Papaya. After having his prey scared away by Guava, Papaya begins to explain the different hardships and dangers that tigers face in their natural habitat. Papaya also teaches Guava about the different programs and activities that humans have been doing to help increase and restore tiger populations. At the end of the story, Guava returns to his world and spreads awareness to those that live in Serenia about how tigers are threatened in other places and what’s being done to help them. Papaya uses basic ecological concepts to explain the importance of tigers in their ecosystem. These concepts include habitat loss, trophic levels, landscape fragmentation, and poaching. The story also incorporates different conservation methods, including captive breeding and the use of camera traps.
ContributorsMooney, Lena (Author) / Jesse, Lewis (Thesis director) / Meloy, Elizabeth (Committee member) / College of Integrative Sciences and Arts (Contributor, Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Food provides nutrients and sustenance that are essential to life. Humans rely on food to fuel our thoughts and actions. However, food isn’t just a source of energy; it’s a fundamental part of culture and connection. Simply sharing a meal with someone can build teamwork and create a bond. Throughout this short memoir, I explored the ways in which food creates a connection across language and cultural barriers through reflection on specific experiences that I had in India, Uganda, and South Africa. While my experiences in each of these three countries were vastly different, there was one defining theme that brought them together: food. This memoir uses mixed media (personal reflection, research, recipes, and photos) to connect the three different international experiences. Reflection on my own family traditions and history bridges the gap between my upbringing and my interactions with people while spending time abroad. Popular recipes from each of the three countries are mixed into the personal reflection, showing how preparing food in a different geographic location can change the experience of preparation and eating. In addition to personal experience, included is a synthesis of research done on the effects of sharing a plate or a meal on negotiations tactics, how eating the same food increases trust, the ways in which food sharing is an act of social intimacy, and how it can build community. Food is an important part of family connection, a tool in many rituals such as Sunday dinners or breaking bread, a critical aspect of many religions, and is tied to the celebration of both birth and death in cultures around the globe. We all need to eat; food is the great commonality among people.
ContributorsRivard-Lentz, Haley Marie Anne (Co-author) / Rivard-Lentz, Haley (Co-author) / Fette, Donald (Thesis director) / Jacobs, Mark (Committee member) / School of Sustainability (Contributor) / School of Public Affairs (Contributor) / Watts College of Public Service & Community Solut (Contributor) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Optical Communications are at a high point of interest by the space engineering community. After successful projects like the Lunar Laser Communications Demonstration (LLCD), NASA has become interested in augmenting their current Deep Space Network (DSN) with optical communication links. One such link is Deep Space Optical Communications (DSOC) which will be launching with the Psyche mission. To gain a full understanding of the advantages of this network, this thesis will go over the history and benefits of optical communications both on Earth and in space. This thesis will then go in depth on NASAs DSOC project through an algorithmic implementation of the communications channel.
ContributorsHorton, Paul Alexander (Author) / Mauskopf, Philip (Thesis director) / Sandy, Douglas (Committee member) / Martin, Thomas (Committee member) / Software Engineering (Contributor) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2018-05
Description
This project, Building the Backdrop, Expanding Perspectives on Sustainability, is a sculpture of a desert sunset that seeks to explore important sustainability issues and highlight the beauty in sustainable practices. Constructed for an honors thesis project at Arizona State University, the primary medium used was cardboard repurposed from package deliveries to bring attention to modern overconsumption of packaging materials and showcase our ability to give new life to traditionally single use materials. I invite you to interact with the piece by sharing photos of yourself in front of it to help spread its message and exploring the resources shared along with the sculpture.
ContributorsSandoval, Nicole (Author) / Hines, Taylor (Thesis director) / Meissinger, Ellen (Committee member) / Barrett, The Honors College (Contributor) / Department of Supply Chain Management (Contributor) / Dean, W.P. Carey School of Business (Contributor) / College of Integrative Sciences and Arts (Contributor)
Created2024-05
Description
A guidebook meant to be used by the leadership of the club Poly Purrs. It includes definitions of key terms as well as literature-backed discussion of free-roaming cats in general. The second half of it is advice and information drawn from my own experience with the cat population on the Polytechnic campus.
ContributorsWiese, Alexa (Author) / Murphree, Julie (Thesis director) / Gallaway, Cynthia (Committee member) / Barrett, The Honors College (Contributor) / College of Integrative Sciences and Arts (Contributor)
Created2024-05
Description
We discuss the intricate and puzzling concept of quantum entanglement, and not only
define it but also consider the implications of the behaviors of entangled particles. The ability of
these particles to provide instantaneous information about their entangled counterparts sparked a debate among physicists as to whether or not these particles had definite quantities before
measurement, and whether or not their behaviors could be explained by a local hidden-variables
theorem. Mermin’s gedanken demonstration for a two-particle entangled system is introduced, as well as Bell’s inequality, and an explanation of how a pair of two entangled particles violate this inequality. Additionally, we also discuss various experimental verifications that were able to use Bell’s inequality to verify the expected quantum mechanical results for their entangled systems.
ContributorsDavis, Elsie (Author) / Foy, Joseph (Thesis director) / Hines, Taylor (Committee member) / Barrett, The Honors College (Contributor) / College of Integrative Sciences and Arts (Contributor)
Created2024-05
Description
Terrestrial hermit crabs serve an incredibly important ecological role in seed dispersal and as decomposers along coastal shorelines. They have also become quite popular in the commercial pet trade, with one species, Coenobita clypeatus, being particularly favored. Typically, these hermit crabs are easily captured and removed from the wild with little protection in their native ranges. In Hermitage Bay, Tobago, there is little information about the population numbers, composition, shell preference, and substrate preference of C. clypeatus in their native habitat. In this study, we estimated population size, gastropod shell preferences, and substrate preference conditions when clustering. We conducted mark re-capture surveys in March, July, and December 2023 and collected morphological data from captured hermit crabs. Our results indicate that the estimated population was highest in July, with the variation being significant when using the Schnabel mark re-capture estimation formula. The most common overall shell type, Columbella mercatoria (West Indian Dove Shell), was prevalent among the smaller sized, younger hermit crabs; while the larger hermit crabs preferred Cittarium pica (West Indian Top Shell). The most preferred substrate for these terrestrial hermit crabs were areas with a mixture of sand and dirt, with high amounts of vegetation and leaf waste and low amounts of human litter. These results suggest a predominantly young population and that beach cleanups should focus on removing human litter entirely, while leaving leaf waste and other fallen logs and branches and not using the collected decomposing plant matter for bonfires. This can help maintain a healthy hermit crab population that continues to benefit the coastlines in Tobago as well as other ecosystems.
ContributorsLindteigen, Amy (Author) / Briggs, Georgette (Thesis director) / Mohammed, Ryan (Committee member) / Barrett, The Honors College (Contributor) / College of Integrative Sciences and Arts (Contributor) / Dean, W.P. Carey School of Business (Contributor)
Created2024-05
Description
Chisholm’s contrary-to-duty paradox raises important questions for formulating instances of conditional obligation. Angelika Kratzer is one linguist whose theories offer some solutions to these questions; more generally, she provides theories for how we should represent modals, conditionals, and other features of language in terms of functions. Though her theories are incredibly useful, they do not adequately represent the Chisholm scenario as a whole. In this paper, I attempt to address this shortcoming in her theory. First, I present and explain some of Kratzer’s main ideas. Then, I explain how her theory offers a solution to Chisholm’s Paradox, and examine a shortcoming of her theory as presented– specifically, the fact that her theory does not account for the importance of different norms in relation to each other. Finally, with the Chisholm situation as a backdrop, I offer my own contribution to her theory. Namely, I propose assigning an importance “score” to each norm, and factoring that “score” into the machinery of Kratzer’s theory.
ContributorsBrooks, Elizabeth (Author) / nair, shyam (Thesis director) / Pinillos, Angel (Committee member) / Barrett, The Honors College (Contributor) / College of Integrative Sciences and Arts (Contributor) / Historical, Philosophical & Religious Studies, Sch (Contributor)
Created2024-05