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Description
The dissolution of metal layers such as silver into chalcogenide glass layers such as germanium selenide changes the resistivity of the metal and chalcogenide films by a great extent. It is known that the incorporation of the metal can be achieved by ultra violet light exposure or thermal processes. In this work, the use of metal dissolution by exposure to gamma radiation has been explored for radiation sensor applications. Test structures were designed and a process flow was developed for prototype sensor fabrication. The test structures were designed such that sensitivity to radiation could be studied. The focus is on the effect of gamma rays as well as ultra violet light on silver dissolution in germanium selenide (Ge30Se70) chalcogenide glass. Ultra violet radiation testing was used prior to gamma exposure to assess the basic mechanism. The test structures were electrically characterized prior to and post irradiation to assess resistance change due to metal dissolution. A change in resistance was observed post irradiation and was found to be dependent on the radiation dose. The structures were also characterized using atomic force microscopy and roughness measurements were made prior to and post irradiation. A change in roughness of the silver films on Ge30Se70 was observed following exposure. This indicated the loss of continuity of the film which causes the increase in silver film resistance following irradiation. Recovery of initial resistance in the structures was also observed after the radiation stress was removed. This recovery was explained with photo-stimulated deposition of silver from the chalcogenide at room temperature confirmed with the re-appearance of silver dendrites on the chalcogenide surface. The results demonstrate that it is possible to use the metal dissolution effect in radiation sensing applications.
ContributorsChandran, Ankitha (Author) / Kozicki, Michael N (Thesis advisor) / Holbert, Keith E. (Committee member) / Barnaby, Hugh (Committee member) / Arizona State University (Publisher)
Created2012
Description
In this work, a highly sensitive strain sensing technique is developed to realize in-plane strain mapping for microelectronic packages or emerging flexible or foldable devices, where mechanical or thermal strain is a major concern that could affect the performance of the working devices or even lead to the failure of the devices. Therefore strain sensing techniques to create a contour of the strain distribution is desired.
The developed highly sensitive micro-strain sensing technique differs from the existing strain mapping techniques, such as digital image correlation (DIC)/micro-Moiré techniques, in terms of working mechanism, by filling a technology gap that requires high spatial resolution while simultaneously maintaining a large field-of-view. The strain sensing mechanism relies on the scanning of a tightly focused laser beam onto the grating that is on the sample surface to detect the change in the diffracted beam angle as a result of the strain. Gratings are fabricated on the target substrates to serve as strain sensors, which carries the strain information in the form of variations in the grating period. The geometric structure of the optical system inherently ensures the high sensitivity for the strain sensing, where the nanoscale change of the grating period is amplified by almost six orders into a diffraction peak shift on the order of several hundred micrometers. It significantly amplifies the small signal measurements so that the desired sensitivity and accuracy can be achieved.
The important features, such as strain sensitivity and spatial resolution, for the strain sensing technique are investigated to evaluate the technique. The strain sensitivity has been validated by measurements on homogenous materials with well known reference values of CTE (coefficient of thermal expansion). 10 micro-strain has been successfully resolved from the silicon CTE extraction measurements. Furthermore, the spatial resolution has been studied on predefined grating patterns, which are assembled to mimic the uneven strain distribution across the sample surface. A resolvable feature size of 10 µm has been achieved with an incident laser spot size of 50 µm in diameter.
In addition, the strain sensing technique has been applied to a composite sample made of SU8 and silicon, as well as the microelectronic packages for thermal strain mappings.
The developed highly sensitive micro-strain sensing technique differs from the existing strain mapping techniques, such as digital image correlation (DIC)/micro-Moiré techniques, in terms of working mechanism, by filling a technology gap that requires high spatial resolution while simultaneously maintaining a large field-of-view. The strain sensing mechanism relies on the scanning of a tightly focused laser beam onto the grating that is on the sample surface to detect the change in the diffracted beam angle as a result of the strain. Gratings are fabricated on the target substrates to serve as strain sensors, which carries the strain information in the form of variations in the grating period. The geometric structure of the optical system inherently ensures the high sensitivity for the strain sensing, where the nanoscale change of the grating period is amplified by almost six orders into a diffraction peak shift on the order of several hundred micrometers. It significantly amplifies the small signal measurements so that the desired sensitivity and accuracy can be achieved.
The important features, such as strain sensitivity and spatial resolution, for the strain sensing technique are investigated to evaluate the technique. The strain sensitivity has been validated by measurements on homogenous materials with well known reference values of CTE (coefficient of thermal expansion). 10 micro-strain has been successfully resolved from the silicon CTE extraction measurements. Furthermore, the spatial resolution has been studied on predefined grating patterns, which are assembled to mimic the uneven strain distribution across the sample surface. A resolvable feature size of 10 µm has been achieved with an incident laser spot size of 50 µm in diameter.
In addition, the strain sensing technique has been applied to a composite sample made of SU8 and silicon, as well as the microelectronic packages for thermal strain mappings.
ContributorsLiang, Hanshuang (Author) / Yu, Hongbin (Thesis advisor) / Poon, Poh Chieh Benny (Committee member) / Jiang, Hanqing (Committee member) / Zhang, Yong-Hang (Committee member) / Arizona State University (Publisher)
Created2014
Description
In this thesis, an approach to develop low-frequency accelerometer based on molecular electronic transducers (MET) in an electrochemical cell is presented. Molecular electronic transducers are a class of inertial sensors which are based on an electrochemical mechanism. Motion sensors based on MET technology consist of an electrochemical cell that can be used to detect the movement of liquid electrolyte between electrodes by converting it to an output current. Seismometers based on MET technology are attractive for planetary applications due to their high sensitivity, low noise, small size and independence on the direction of sensitivity axis. In addition, the fact that MET based sensors have a liquid inertial mass with no moving parts makes them rugged and shock tolerant (basic survivability has been demonstrated to >20 kG).
A Zn-Cu electrochemical cell (Galvanic cell) was applied in the low-frequency accelerometer. Experimental results show that external vibrations (range from 18 to 70 Hz) were successfully detected by this accelerometer as reactions Zn→〖Zn〗^(2+)+2e^- occurs around the anode and 〖Cu〗^(2+)+2e^-→Cu around the cathode. Accordingly, the sensitivity of this MET device design is to achieve 10.4 V/G at 18 Hz. And the sources of noise have been analyzed.
A Zn-Cu electrochemical cell (Galvanic cell) was applied in the low-frequency accelerometer. Experimental results show that external vibrations (range from 18 to 70 Hz) were successfully detected by this accelerometer as reactions Zn→〖Zn〗^(2+)+2e^- occurs around the anode and 〖Cu〗^(2+)+2e^-→Cu around the cathode. Accordingly, the sensitivity of this MET device design is to achieve 10.4 V/G at 18 Hz. And the sources of noise have been analyzed.
ContributorsZhao, Zuofeng (Author) / Yu, Hongyu (Thesis advisor) / Zhang, Junshan (Committee member) / Jiang, Hanqing (Committee member) / Arizona State University (Publisher)
Created2015
Description
Cisco estimates that by 2020, 50 billion devices will be connected to the Internet. But 99% of the things today remain isolated and unconnected. Different connectivity protocols, proprietary access, varied device characteristics, security concerns are the main reasons for that isolated state. This project aims at designing and building a prototype gateway that exposes a simple and intuitive HTTP Restful interface to access and manipulate devices and the data that they produce while addressing most of the issues listed above. Along with manipulating devices, the framework exposes sensor data in such a way that it can be used to create applications like rules or events that make the home smarter. It also allows the user to represent high-level knowledge by aggregating the low-level sensor data. This high-level representation can be considered as a property of the environment or object rather than the sensor itself which makes interpreting the values more intuitive and accessible.
ContributorsNair, Shankar (Author) / Lee, Yann-Hang (Thesis advisor) / Lee, Joohyung (Committee member) / Fainekos, Georgios (Committee member) / Arizona State University (Publisher)
Created2015
Description
Proton beam therapy (PBT) is a state-of-the-art radiotherapy treatment approach that uses focused proton beams for tumor ablation. A key advantage of this approach over conventional photon radiotherapy (XRT) is the unique dose deposition characteristics of protons, resulting in superior healthy tissue sparing. This results in fewer unwanted side effects and improved outcomes for patients. Current available dosimeters are intrinsic, complex and expensive; hence cannot be used to determine the dose delivered to the tumor routinely. Here, we report a hydrogel based plasmonic nanosensor for measurements of clinical doses in ranges between 2-4 GyRBE. In this nanosensor, gold ions, encapsulated in a hydrogel, are reduced to gold nanoparticles following irradiation with proton beams. Formation of gold nanoparticles renders a color change to the originally colorless hydrogel. The intensity of the color can be used to calibrate the hydrogel nanosensor in order to quantify different radiation doses employed during treatment. The potential of this nanosensor for clinical translation was demonstrated using an anthropomorphic phantom mimicking a clinical radiotherapy session. The simplicity of fabrication, detection range in the fractionated radiotherapy regime and ease of detection with translational potential makes this a first-in-kind plasmonic colorimetric nanosensor for applications in clinical proton beam therapy.
ContributorsInamdar, Sahil (Author) / Rege, Kaushal (Thesis advisor) / Anand, Aman (Committee member) / Nannenga, Brent (Committee member) / Arizona State University (Publisher)
Created2017
Description
Laser radars or lidar’s have been used extensively to remotely study winds within the atmospheric boundary layer and atmospheric transport. Lidar sensors have become an important tool within the meteorology and the wind energy community. For example, Doppler lidars are used frequently in wind resource assessment, wind turbine control as well as in atmospheric science research. A Time of Flight based (ToF) direct detection lidar sensor is used in vehicles to navigate through complex and dynamic environments autonomously. These optical sensors are used to map the environment around the car accurately for perception and localization tasks that help achieve complete autonomy.
This thesis begins with a detailed discussion on the fundamentals of a Doppler lidar system. The laser signal flow path to and from the target, the optics of the system and the core signal processing algorithms used to extract velocity information, were studied to get closer to the hardware of a Doppler lidar sensor. A Doppler lidar simulator was built to study the existing signal processing algorithms to detect and estimate doppler frequency, and radial velocity information. Understanding the sensor and its processing at the hardware level is necessary to develop new algorithms to detect and track specific flow structures in the atmosphere. For example, the aircraft vortices have been a topic of extensive research and doppler lidars have proved to be a valuable sensor to detect and track these coherent flow structures. Using the lidar simulator a physics based doppler lidar vortex algorithm is tested on simulated data to track a pair of counter rotating aircraft vortices.
At a system level the major components of a time of flight lidar is very similar to a Doppler lidar. The fundamental physics of operation is however different. While doppler lidars are used for radial velocity measurement, ToF sensors as the name suggests provides precise depth measurements by measuring time of flight between the transmitted and the received pulses. The second part of this dissertation begins to explore the details of ToF lidar system. A system level design, to build a ToF direct detection lidar system is presented. Different lidar sensor modalities that are currently used with sensors in the market today for automotive applications were evaluated and a 2D MEMS based scanning lidar system was designed using off-the shelf components.
Finally, a range of experiments and tests were completed to evaluate the performance of each sub-component of the lidar sensor prototype. A major portion of the testing was done to align the optics of the system and to ensure maximum field of view overlap for the bi-static laser sensor. As a laser range finder, the system demonstrated capabilities to detect hard targets as far as 32 meters. Time to digital converter (TDC) and an analog to digital converter (ADC) was used for providing accurate timing solutions for the lidar prototype. A Matlab lidar model was built and used to perform trade-off studies that helped choosing components to suit the sensor design specifications.
The size, weight and cost of these lidar sensors are still very high and thus making it harder for automotive manufacturers to integrate these sensors into their vehicles. Ongoing research in this field is determined to find a solution that guarantees very high performance in real time and lower its cost over the next decade as components get cheaper and can be seamlessly integrated with cars to improve on-road safety.
This thesis begins with a detailed discussion on the fundamentals of a Doppler lidar system. The laser signal flow path to and from the target, the optics of the system and the core signal processing algorithms used to extract velocity information, were studied to get closer to the hardware of a Doppler lidar sensor. A Doppler lidar simulator was built to study the existing signal processing algorithms to detect and estimate doppler frequency, and radial velocity information. Understanding the sensor and its processing at the hardware level is necessary to develop new algorithms to detect and track specific flow structures in the atmosphere. For example, the aircraft vortices have been a topic of extensive research and doppler lidars have proved to be a valuable sensor to detect and track these coherent flow structures. Using the lidar simulator a physics based doppler lidar vortex algorithm is tested on simulated data to track a pair of counter rotating aircraft vortices.
At a system level the major components of a time of flight lidar is very similar to a Doppler lidar. The fundamental physics of operation is however different. While doppler lidars are used for radial velocity measurement, ToF sensors as the name suggests provides precise depth measurements by measuring time of flight between the transmitted and the received pulses. The second part of this dissertation begins to explore the details of ToF lidar system. A system level design, to build a ToF direct detection lidar system is presented. Different lidar sensor modalities that are currently used with sensors in the market today for automotive applications were evaluated and a 2D MEMS based scanning lidar system was designed using off-the shelf components.
Finally, a range of experiments and tests were completed to evaluate the performance of each sub-component of the lidar sensor prototype. A major portion of the testing was done to align the optics of the system and to ensure maximum field of view overlap for the bi-static laser sensor. As a laser range finder, the system demonstrated capabilities to detect hard targets as far as 32 meters. Time to digital converter (TDC) and an analog to digital converter (ADC) was used for providing accurate timing solutions for the lidar prototype. A Matlab lidar model was built and used to perform trade-off studies that helped choosing components to suit the sensor design specifications.
The size, weight and cost of these lidar sensors are still very high and thus making it harder for automotive manufacturers to integrate these sensors into their vehicles. Ongoing research in this field is determined to find a solution that guarantees very high performance in real time and lower its cost over the next decade as components get cheaper and can be seamlessly integrated with cars to improve on-road safety.
ContributorsBhaskaran, Sreevatsan (Author) / Calhoun, Ronald J (Thesis advisor) / Dahm, Werner (Committee member) / Huang, Huei-Ping (Committee member) / Chen, Kang Pin (Committee member) / Choukulkar, Aditya (Committee member) / Arizona State University (Publisher)
Created2018
Description
The instrumentational measurement of seismic motion is important for a wide range of research fields and applications, such as seismology, geology, physics, civil engineering and harsh environment exploration. This report presents series approaches to develop Micro-Electro-Mechanical System (MEMS) enhanced inertial motion sensors including accelerometers, seismometers and inclinometers based on Molecular Electronic Transducers (MET) techniques.
Seismometers based on MET technology are attractive for planetary applications due to their high sensitivity, low noise floor, small size, absence of fragile mechanical moving parts and independence on the direction of sensitivity axis. By using MEMS techniques, a micro MET seismometer is developed with inter-electrode spacing close to 5 μm. The employment of MEMS improves the sensitivity of fabricated device to above 2500 V/(m/s2) under operating bias of 300 mV and input velocity of 8.4μm/s from 0.08Hz to 80Hz. The lowered hydrodynamic resistance by increasing the number of channels improves the self-noise to -135 dB equivalent to 18nG/√Hz (G=9.8m/s2) around 1.2 Hz.
Inspired by the advantages of combining MET and MEMS technologies on the development of seismometer, a feasibility study of development of a low frequency accelerometer utilizing MET technology with post-CMOS-compatible fabrication processes is performed. In the fabricated accelerometer, the complicated fabrication of mass-spring system in solid-state MEMS accelerometer is replaced with a much simpler post-CMOS-compatible process containing only deposition of a four-electrode MET structure on a planar substrate, and a liquid inertia mass of an electrolyte droplet. With a specific design of 3D printing based package and replace water based iodide solution by room temperature ionic liquid based electrolyte, the sensitivity relative to the ground motion can reach 103.69V/g, with the resolution of 5.25μG/√Hz at 1Hz.
By combining MET techniques and Zn-Cu electrochemical cell (Galvanic cell), this letter demonstrates a passive motion sensor powered by self-electrochemistry energy, named “Battery Accelerometer”. The experimental results indicated the peak sensitivity of battery accelerometer at its resonant frequency 18Hz is 10.4V/G with the resolution of 1.71μG without power consumption.
Seismometers based on MET technology are attractive for planetary applications due to their high sensitivity, low noise floor, small size, absence of fragile mechanical moving parts and independence on the direction of sensitivity axis. By using MEMS techniques, a micro MET seismometer is developed with inter-electrode spacing close to 5 μm. The employment of MEMS improves the sensitivity of fabricated device to above 2500 V/(m/s2) under operating bias of 300 mV and input velocity of 8.4μm/s from 0.08Hz to 80Hz. The lowered hydrodynamic resistance by increasing the number of channels improves the self-noise to -135 dB equivalent to 18nG/√Hz (G=9.8m/s2) around 1.2 Hz.
Inspired by the advantages of combining MET and MEMS technologies on the development of seismometer, a feasibility study of development of a low frequency accelerometer utilizing MET technology with post-CMOS-compatible fabrication processes is performed. In the fabricated accelerometer, the complicated fabrication of mass-spring system in solid-state MEMS accelerometer is replaced with a much simpler post-CMOS-compatible process containing only deposition of a four-electrode MET structure on a planar substrate, and a liquid inertia mass of an electrolyte droplet. With a specific design of 3D printing based package and replace water based iodide solution by room temperature ionic liquid based electrolyte, the sensitivity relative to the ground motion can reach 103.69V/g, with the resolution of 5.25μG/√Hz at 1Hz.
By combining MET techniques and Zn-Cu electrochemical cell (Galvanic cell), this letter demonstrates a passive motion sensor powered by self-electrochemistry energy, named “Battery Accelerometer”. The experimental results indicated the peak sensitivity of battery accelerometer at its resonant frequency 18Hz is 10.4V/G with the resolution of 1.71μG without power consumption.
ContributorsLiang, Mengbing (Author) / Yu, Hongyu (Thesis advisor) / Dai, Lenore (Committee member) / Kozicki, Michael (Committee member) / Jiang, Hanqing (Committee member) / Arizona State University (Publisher)
Created2016
Description
Presented below is the design and fabrication of prosthetic components consisting of an attachment, tactile sensing, and actuator systems with Fused Filament Fabrication (FFF) technique. The attachment system is a thermoplastic osseointegrated upper limb prosthesis for average adult trans-humeral amputation with mechanical properties greater than upper limb skeletal bone. The prosthetic designed has: a one-step surgical process, large cavities for bone tissue ingrowth, uses a material that has an elastic modulus less than skeletal bone, and can be fabricated on one system.
FFF osseointegration screw is an improvement upon the current two-part osseointegrated prosthetics that are composed of a fixture and abutment. The current prosthetic design requires two invasive surgeries for implantation and are made of titanium, which has an elastic modulus greater than bone. An elastic modulus greater than bone causes stress shielding and overtime can cause loosening of the prosthetic.
The tactile sensor is a thermoplastic piezo-resistive sensor for daily activities for a prosthetic’s feedback system. The tactile sensor is manufactured from a low elastic modulus composite comprising of a compressible thermoplastic elastomer and conductive carbon. Carbon is in graphite form and added in high filler ratios. The printed sensors were compared to sensors that were fabricated in a gravity mold to highlight the difference in FFF sensors to molded sensors. The 3D printed tactile sensor has a thickness and feel similar to human skin, has a simple fabrication technique, can detect forces needed for daily activities, and can be manufactured in to user specific geometries.
Lastly, a biomimicking skeletal muscle actuator for prosthetics was developed. The actuator developed is manufactured with Fuse Filament Fabrication using a shape memory polymer composite that has non-linear contractile and passive forces, contractile forces and strains comparable to mammalian skeletal muscle, reaction time under one second, low operating temperature, and has a low mass, volume, and material costs. The actuator improves upon current prosthetic actuators that provide rigid, linear force with high weight, cost, and noise.
FFF osseointegration screw is an improvement upon the current two-part osseointegrated prosthetics that are composed of a fixture and abutment. The current prosthetic design requires two invasive surgeries for implantation and are made of titanium, which has an elastic modulus greater than bone. An elastic modulus greater than bone causes stress shielding and overtime can cause loosening of the prosthetic.
The tactile sensor is a thermoplastic piezo-resistive sensor for daily activities for a prosthetic’s feedback system. The tactile sensor is manufactured from a low elastic modulus composite comprising of a compressible thermoplastic elastomer and conductive carbon. Carbon is in graphite form and added in high filler ratios. The printed sensors were compared to sensors that were fabricated in a gravity mold to highlight the difference in FFF sensors to molded sensors. The 3D printed tactile sensor has a thickness and feel similar to human skin, has a simple fabrication technique, can detect forces needed for daily activities, and can be manufactured in to user specific geometries.
Lastly, a biomimicking skeletal muscle actuator for prosthetics was developed. The actuator developed is manufactured with Fuse Filament Fabrication using a shape memory polymer composite that has non-linear contractile and passive forces, contractile forces and strains comparable to mammalian skeletal muscle, reaction time under one second, low operating temperature, and has a low mass, volume, and material costs. The actuator improves upon current prosthetic actuators that provide rigid, linear force with high weight, cost, and noise.
ContributorsLathers, Steven (Author) / La Belle, Jeffrey (Thesis advisor) / Vowels, David (Committee member) / Lockhart, Thurmon (Committee member) / Abbas, James (Committee member) / McDaniel, Troy (Committee member) / Arizona State University (Publisher)
Created2017
Description
Video capture, storage, and distribution in wireless video sensor networks
(WVSNs) critically depends on the resources of the nodes forming the sensor
networks. In the era of big data, Internet of Things (IoT), and distributed
demand and solutions, there is a need for multi-dimensional data to be part of
the Sensor Network data that is easily accessible and consumable by humanity as
well as machinery. Images and video are expected to become as ubiquitous as is
the scalar data in traditional sensor networks. The inception of video-streaming
over the Internet, heralded a relentless research for effective ways of
distributing video in a scalable and cost effective way. There has been novel
implementation attempts across several network layers. Due to the inherent
complications of backward compatibility and need for standardization across
network layers, there has been a refocused attention to address most of the
video distribution over the application layer. As a result, a few video
streaming solutions over the Hypertext Transfer Protocol (HTTP) have been
proposed. Most notable are Apple’s HTTP Live Streaming (HLS) and the Motion
Picture Experts Groups Dynamic Adaptive Streaming over HTTP (MPEG-DASH). These
frameworks, do not address the typical and future WVSN use cases. A highly
flexible Wireless Video Sensor Network Platform and compatible DASH (WVSNP-DASH)
are introduced. The platform's goal is to usher video as a data element that
can be integrated into traditional and non-Internet networks. A low cost,
scalable node is built from the ground up to be fully compatible with the
Internet of Things Machine to Machine (M2M) concept, as well as the ability to
be easily re-targeted to new applications in a short time. Flexi-WVSNP design
includes a multi-radio node, a middle-ware for sensor operation and
communication, a cross platform client facing data retriever/player framework,
scalable security as well as a cohesive but decoupled hardware and software
design.
(WVSNs) critically depends on the resources of the nodes forming the sensor
networks. In the era of big data, Internet of Things (IoT), and distributed
demand and solutions, there is a need for multi-dimensional data to be part of
the Sensor Network data that is easily accessible and consumable by humanity as
well as machinery. Images and video are expected to become as ubiquitous as is
the scalar data in traditional sensor networks. The inception of video-streaming
over the Internet, heralded a relentless research for effective ways of
distributing video in a scalable and cost effective way. There has been novel
implementation attempts across several network layers. Due to the inherent
complications of backward compatibility and need for standardization across
network layers, there has been a refocused attention to address most of the
video distribution over the application layer. As a result, a few video
streaming solutions over the Hypertext Transfer Protocol (HTTP) have been
proposed. Most notable are Apple’s HTTP Live Streaming (HLS) and the Motion
Picture Experts Groups Dynamic Adaptive Streaming over HTTP (MPEG-DASH). These
frameworks, do not address the typical and future WVSN use cases. A highly
flexible Wireless Video Sensor Network Platform and compatible DASH (WVSNP-DASH)
are introduced. The platform's goal is to usher video as a data element that
can be integrated into traditional and non-Internet networks. A low cost,
scalable node is built from the ground up to be fully compatible with the
Internet of Things Machine to Machine (M2M) concept, as well as the ability to
be easily re-targeted to new applications in a short time. Flexi-WVSNP design
includes a multi-radio node, a middle-ware for sensor operation and
communication, a cross platform client facing data retriever/player framework,
scalable security as well as a cohesive but decoupled hardware and software
design.
ContributorsSeema, Adolph (Author) / Reisslein, Martin (Thesis advisor) / Kitchen, Jennifer (Committee member) / Seeling, Patrick (Committee member) / Zhang, Yanchao (Committee member) / Arizona State University (Publisher)
Created2017
Description
The American Diabetes Association reports that diabetes costs $322 billion annually and affects 29.1 million Americans. The high out-of-pocket cost of managing diabetes can lead to noncompliance causing serious and expensive complications. There is a large market potential for a more cost-effective alternative to the current market standard of screen-printed self-monitoring blood glucose (SMBG) strips. Additive manufacturing, specifically 3D printing, is a developing field that is growing in popularity and functionality. 3D printers are now being used in a variety of applications from consumer goods to medical devices. Healthcare delivery will change as the availability of 3D printers expands into patient homes, which will create alternative and more cost-effective methods of monitoring and managing diseases, such as diabetes. 3D printing technology could transform this expensive industry. A 3D printed sensor was designed to have similar dimensions and features to the SMBG strips to comply with current manufacturing standards. To make the sensor electrically active, various conductive filaments were tested and the conductive graphene filament was determined to be the best material for the sensor. Experiments were conducted to determine the optimal print settings for printing this filament onto a mylar substrate, the industry standard. The reagents used include a mixture of a ferricyanide redox mediator and flavin adenine dinucleotide dependent glucose dehydrogenase. With these materials, each sensor only costs $0.40 to print and use. Before testing the 3D printed sensor, a suitable design, voltage range, and redox probe concentration were determined. Experiments demonstrated that this novel 3D printed sensor can accurately correlate current output to glucose concentration. It was verified that the sensor can accurately detect glucose levels from 25 mg/dL to 400 mg/dL, with an R2 correlation value as high as 0.97, which was critical as it covered hypoglycemic to hyperglycemic levels. This demonstrated that a 3D-printed sensor was created that had characteristics that are suitable for clinical use. This will allow diabetics to print their own test strips at home at a much lower cost compared to SMBG strips, which will reduce noncompliance due to the high cost of testing. In the future, this technology could be applied to additional biomarkers to measure and monitor other diseases.
ContributorsAdams, Anngela (Author) / LaBelle, Jeffrey (Thesis advisor) / Pizziconi, Vincent (Committee member) / Abbas, James (Committee member) / Arizona State University (Publisher)
Created2017