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The purpose of this project was to research the expression of Autism Spectrum Disorder in children and create a children’s book that can help the peers of individuals with a diagnosis to understand what the disorder entails and potentially gain a new sense of empathy for peers of all levels of physical and mental abilities. The research component includes interviews with individuals deemed knowledgeable about ASD, including occupational therapists, behavioral analysts, and parents, as well as a literature review of research studies on the expression of Autism in children. This written portion of the project may also serve as a manual for individuals who have little to no knowledge of ASD, as it dives deeper into the content of the book and research, while remaining easily understandable and clear to those without any prior knowledge or experience with ASD. It could prove especially useful for those in professions that come into contact with individuals with Autism, but do not necessarily require psychology courses or training as a prerequisite for the role, such as teachers and some health professionals.
Indian-American young adults are often caught between the cultures of their parents and their environment, and these two cultures can impact their views based on the cultures' views. In this project, I created an overview of personal accounts of Indian-American young adults on their experiences with mental health struggles, and receiving counseling and treatment. This study analyzed a sample of accounts and testimonials previously collected through a qualitative review. I found that many of the Indian-American young adults were open to mental health counseling and treatment, but saw Indian cultural views as a barrier.
Does training in the upper extremity domain with startle translate to the speech domain post-stroke?
The aim of this study was to assess whether exposing individuals who are 6-month post-stroke with an upper extremity motor deficit and some form of speech impairment (aphasia and/or apraxia) to upper extremity training utilizing Startle Adjuvant Rehabilitation Therapy (START) would result in improvement in symptoms of speech impairment. It was hypothesized that while scores on Diadochokinetic Rate (a measure of apraxia) and Repetition (a measure of aphasia) would improve by timepoint with START as compared to the Control group, measures of aphasia including Spontaneous Speech, Auditory Verbal Comprehension, and Naming would not be different in scores by timepoint. Subjects were recruited from two separate ongoing studies consisting of three days of similar upper extremity training on certain functional tasks with and without START and the speech assessments utilized were pulled from the Western Aphasia Battery (Revised) and Apraxia Battery for Adults 2nd Edition. It was found that there were no statistically significant differences by timepoint in either condition for any of the speech assessments. This proof-of-concept study is the first to assess whether the StartReact effect, when applied to the upper extremity domain, will translate into measurable improvements in speech impairment despite the lack of any speech training.
The purpose of this study was to evaluate the quality of life in the participating families of the Babble Boot Camp. The Babble Boot Camp provides speech therapy for children with classic galactosemia starting as early as two months old. The child’s speech progress is evaluated along with other metrics such as parental and child stress levels and quality of life. In this study, the quality of life of the participants in the Babble Boot Camp was evaluated using the Pediatric Quality of Life questionnaire (Varni, 1998). A comparative study was conducted between mothers and fathers, families with children with classic galactosemia, and with typically developing children, and the effects of speech therapy earlier in a child’s life versus later. The questions looked into in this study were if mothers and fathers report different quality of life scores, if there is a correlation between the scores the children have for the quality of life and the scores the parents received for the quality of life, differences in quality of life scores of parents with children with classic galactosemia and parents with typically developing children, and if the quality of life scores of parents and children improve in the Babble Boot Camp. The main results were that mothers report a lower quality of life than fathers, mothers have a stronger correlation with their children in regards to their quality of life scores, parents with children with classic galactosemia have a lower quality of life scores than parents with typically developing children and parents and children who were in the group who received speech therapy from earlier have a higher quality of life scores than the late group.
humor being a key aspect of psychotherapy, there is relatively little research. In this study, I addressed whether the frequency of therapist humor is related to subsequent therapeutic alliance ratings by the client. I also examined if therapist humor use is related to improvement in client symptomology. I hypothesized that there will be a positive correlation between humor use and the working alliance while there will be a negative correlation between humor use and client symptomology. Video recordings of therapy sessions were coded for humor (defined by laughter present in response to the therapist) or no humor (laughter not present). These ratings were correlated to client perceptions of the working alliance (using the WAI-S) and client symptomology. I found no correlations between humor and changes in working alliance or client symptomology. The results suggest that humor use in counseling does not seem to matter, however possible limitations of the study mitigate such conclusions.
The Molecular Disease Classifier (MDC) was trained on 34,352 cases and tested on 15,473 unambiguously diagnosed cases. The MDC predicted the correct tumor type out of thirteen possibilities in the labeled data set with sensitivity, specificity, PPV, and NPV of 90.5%, 99.2%, 90.5% and 99.2% respectively when considering up to 5 predictions for a case.
The availability of whole transcriptome data in the CMD prompted its inclusion into a new platform called MI GPSai (MI Genomic Prevalence Score). The algorithm trained on genomic data from 34,352 cases and genomic and transcriptomic data from 23,137 cases and was validated on 19,555 cases. MI GPSai can predict the correct tumor type out of 21 possibilities on 93% of cases with 94% accuracy. When considering the top two predictions for a case, the accuracy increases to 97%.
Finally, a 67 gene molecular signature predictive of efficacy of oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer was developed - FOLFOXai. The signature was predictive of survival in an independent real-world evidence (RWE) dataset of 412 patients who had received FOLFOX/BV in 1st line and inversely predictive of survival in RWE data from 55 patients who had received 1st line FOLFIRI. Blinded analysis of TRIBE2 samples confirmed that FOLFOXai was predictive of OS in both oxaliplatin-containing arms (FOLFOX HR=0.629, p=0.04 and FOLFOXIRI HR=0.483, p=0.02).