Matching Items (21)
Filtering by
- All Subjects: Machine Learning
- Genre: Academic theses
- Genre: Masters Thesis
- Creators: Papandreou-Suppappola, Antonia
- Creators: Baral, Chitta
- Member of: Theses and Dissertations
Description
The healthcare system in this country is currently unacceptable. New technologies may contribute to reducing cost and improving outcomes. Early diagnosis and treatment represents the least risky option for addressing this issue. Such a technology needs to be inexpensive, highly sensitive, highly specific, and amenable to adoption in a clinic. This thesis explores an immunodiagnostic technology based on highly scalable, non-natural sequence peptide microarrays designed to profile the humoral immune response and address the healthcare problem. The primary aim of this thesis is to explore the ability of these arrays to map continuous (linear) epitopes. I discovered that using a technique termed subsequence analysis where epitopes could be decisively mapped to an eliciting protein with high success rate. This led to the discovery of novel linear epitopes from Plasmodium falciparum (Malaria) and Treponema palladium (Syphilis), as well as validation of previously discovered epitopes in Dengue and monoclonal antibodies. Next, I developed and tested a classification scheme based on Support Vector Machines for development of a Dengue Fever diagnostic, achieving higher sensitivity and specificity than current FDA approved techniques. The software underlying this method is available for download under the BSD license. Following this, I developed a kinetic model for immunosignatures and tested it against existing data driven by previously unexplained phenomena. This model provides a framework and informs ways to optimize the platform for maximum stability and efficiency. I also explored the role of sequence composition in explaining an immunosignature binding profile, determining a strong role for charged residues that seems to have some predictive ability for disease. Finally, I developed a database, software and indexing strategy based on Apache Lucene for searching motif patterns (regular expressions) in large biological databases. These projects as a whole have advanced knowledge of how to approach high throughput immunodiagnostics and provide an example of how technology can be fused with biology in order to affect scientific and health outcomes.
ContributorsRicher, Joshua Amos (Author) / Johnston, Stephen A. (Thesis advisor) / Woodbury, Neal (Committee member) / Stafford, Phillip (Committee member) / Papandreou-Suppappola, Antonia (Committee member) / Arizona State University (Publisher)
Created2014
Description
Reasoning about the activities of cyber threat actors is critical to defend against cyber
attacks. However, this task is difficult for a variety of reasons. In simple terms, it is difficult
to determine who the attacker is, what the desired goals are of the attacker, and how they will
carry out their attacks. These three questions essentially entail understanding the attacker’s
use of deception, the capabilities available, and the intent of launching the attack. These
three issues are highly inter-related. If an adversary can hide their intent, they can better
deceive a defender. If an adversary’s capabilities are not well understood, then determining
what their goals are becomes difficult as the defender is uncertain if they have the necessary
tools to accomplish them. However, the understanding of these aspects are also mutually
supportive. If we have a clear picture of capabilities, intent can better be deciphered. If we
understand intent and capabilities, a defender may be able to see through deception schemes.
In this dissertation, I present three pieces of work to tackle these questions to obtain
a better understanding of cyber threats. First, we introduce a new reasoning framework
to address deception. We evaluate the framework by building a dataset from DEFCON
capture-the-flag exercise to identify the person or group responsible for a cyber attack.
We demonstrate that the framework not only handles cases of deception but also provides
transparent decision making in identifying the threat actor. The second task uses a cognitive
learning model to determine the intent – goals of the threat actor on the target system.
The third task looks at understanding the capabilities of threat actors to target systems by
identifying at-risk systems from hacker discussions on darkweb websites. To achieve this
task we gather discussions from more than 300 darkweb websites relating to malicious
hacking.
attacks. However, this task is difficult for a variety of reasons. In simple terms, it is difficult
to determine who the attacker is, what the desired goals are of the attacker, and how they will
carry out their attacks. These three questions essentially entail understanding the attacker’s
use of deception, the capabilities available, and the intent of launching the attack. These
three issues are highly inter-related. If an adversary can hide their intent, they can better
deceive a defender. If an adversary’s capabilities are not well understood, then determining
what their goals are becomes difficult as the defender is uncertain if they have the necessary
tools to accomplish them. However, the understanding of these aspects are also mutually
supportive. If we have a clear picture of capabilities, intent can better be deciphered. If we
understand intent and capabilities, a defender may be able to see through deception schemes.
In this dissertation, I present three pieces of work to tackle these questions to obtain
a better understanding of cyber threats. First, we introduce a new reasoning framework
to address deception. We evaluate the framework by building a dataset from DEFCON
capture-the-flag exercise to identify the person or group responsible for a cyber attack.
We demonstrate that the framework not only handles cases of deception but also provides
transparent decision making in identifying the threat actor. The second task uses a cognitive
learning model to determine the intent – goals of the threat actor on the target system.
The third task looks at understanding the capabilities of threat actors to target systems by
identifying at-risk systems from hacker discussions on darkweb websites. To achieve this
task we gather discussions from more than 300 darkweb websites relating to malicious
hacking.
ContributorsNunes, Eric (Author) / Shakarian, Paulo (Thesis advisor) / Ahn, Gail-Joon (Committee member) / Baral, Chitta (Committee member) / Cooke, Nancy J. (Committee member) / Arizona State University (Publisher)
Created2018
Description
This dissertation presents the development of structural health monitoring and prognostic health management methodologies for complex structures and systems in the field of mechanical engineering. To overcome various challenges historically associated with complex structures and systems such as complicated sensing mechanisms, noisy information, and large-size datasets, a hybrid monitoring framework comprising of solid mechanics concepts and data mining technologies is developed. In such a framework, the solid mechanics simulations provide additional intuitions to data mining techniques reducing the dependence of accuracy on the training set, while the data mining approaches fuse and interpret information from the targeted system enabling the capability for real-time monitoring with efficient computation.
In the case of structural health monitoring, ultrasonic guided waves are utilized for damage identification and localization in complex composite structures. Signal processing and data mining techniques are integrated into the damage localization framework, and the converted wave modes, which are induced by the thickness variation due to the presence of delamination, are used as damage indicators. This framework has been validated through experiments and has shown sufficient accuracy in locating delamination in X-COR sandwich composites without the need of baseline information. Besides the localization of internal damage, the Gaussian process machine learning technique is integrated with finite element method as an online-offline prediction model to predict crack propagation with overloads under biaxial loading conditions; such a probabilistic prognosis model, with limited number of training examples, has shown increased accuracy over state-of-the-art techniques in predicting crack retardation behaviors induced by overloads. In the case of system level management, a monitoring framework built using a multivariate Gaussian model as basis is developed to evaluate the anomalous condition of commercial aircrafts. This method has been validated using commercial airline data and has shown high sensitivity to variations in aircraft dynamics and pilot operations. Moreover, this framework was also tested on simulated aircraft faults and its feasibility for real-time monitoring was demonstrated with sufficient computation efficiency.
This research is expected to serve as a practical addition to the existing literature while possessing the potential to be adopted in realistic engineering applications.
In the case of structural health monitoring, ultrasonic guided waves are utilized for damage identification and localization in complex composite structures. Signal processing and data mining techniques are integrated into the damage localization framework, and the converted wave modes, which are induced by the thickness variation due to the presence of delamination, are used as damage indicators. This framework has been validated through experiments and has shown sufficient accuracy in locating delamination in X-COR sandwich composites without the need of baseline information. Besides the localization of internal damage, the Gaussian process machine learning technique is integrated with finite element method as an online-offline prediction model to predict crack propagation with overloads under biaxial loading conditions; such a probabilistic prognosis model, with limited number of training examples, has shown increased accuracy over state-of-the-art techniques in predicting crack retardation behaviors induced by overloads. In the case of system level management, a monitoring framework built using a multivariate Gaussian model as basis is developed to evaluate the anomalous condition of commercial aircrafts. This method has been validated using commercial airline data and has shown high sensitivity to variations in aircraft dynamics and pilot operations. Moreover, this framework was also tested on simulated aircraft faults and its feasibility for real-time monitoring was demonstrated with sufficient computation efficiency.
This research is expected to serve as a practical addition to the existing literature while possessing the potential to be adopted in realistic engineering applications.
ContributorsLi, Guoyi (Ph.D.) (Author) / Chattopadhyay, Aditi (Thesis advisor) / Mignolet, Marc (Committee member) / Papandreou-Suppappola, Antonia (Committee member) / Yekani Fard, Masoud (Committee member) / Jiang, Hanqing (Committee member) / Arizona State University (Publisher)
Created2019
Description
For the past three decades, the design of an effective strategy for generating poetry that matches that of a human’s creative capabilities and complexities has been an elusive goal in artificial intelligence (AI) and natural language generation (NLG) research, and among linguistic creativity researchers in particular. This thesis presents a novel approach to fixed verse poetry generation using neural word embeddings. During the course of generation, a two layered poetry classifier is developed. The first layer uses a lexicon based method to classify poems into types based on form and structure, and the second layer uses a supervised classification method to classify poems into subtypes based on content with an accuracy of 92%. The system then uses a two-layer neural network to generate poetry based on word similarities and word movements in a 50-dimensional vector space.
The verses generated by the system are evaluated using rhyme, rhythm, syllable counts and stress patterns. These computational features of language are considered for generating haikus, limericks and iambic pentameter verses. The generated poems are evaluated using a Turing test on both experts and non-experts. The user study finds that only 38% computer generated poems were correctly identified by nonexperts while 65% of the computer generated poems were correctly identified by experts. Although the system does not pass the Turing test, the results from the Turing test suggest an improvement of over 17% when compared to previous methods which use Turing tests to evaluate poetry generators.
The verses generated by the system are evaluated using rhyme, rhythm, syllable counts and stress patterns. These computational features of language are considered for generating haikus, limericks and iambic pentameter verses. The generated poems are evaluated using a Turing test on both experts and non-experts. The user study finds that only 38% computer generated poems were correctly identified by nonexperts while 65% of the computer generated poems were correctly identified by experts. Although the system does not pass the Turing test, the results from the Turing test suggest an improvement of over 17% when compared to previous methods which use Turing tests to evaluate poetry generators.
ContributorsMagge, Arjun (Author) / Syrotiuk, Violet R. (Thesis advisor) / Baral, Chitta (Committee member) / Hogue, Cynthia (Committee member) / Bazzi, Rida (Committee member) / Arizona State University (Publisher)
Created2016
Description
Biological and biomedical measurements, when adequately analyzed and processed, can be used to impart quantitative diagnosis during primary health care consultation to improve patient adherence to recommended treatments. For example, analyzing neural recordings from neurostimulators implanted in patients with neurological disorders can be used by a physician to adjust detrimental stimulation parameters to improve treatment. As another example, biosequences, such as sequences from peptide microarrays obtained from a biological sample, can potentially provide pre-symptomatic diagnosis for infectious diseases when processed to associate antibodies to specific pathogens or infectious agents. This work proposes advanced statistical signal processing and machine learning methodologies to assess neurostimulation from neural recordings and to extract diagnostic information from biosequences.
For locating specific cognitive and behavioral information in different regions of the brain, neural recordings are processed using sequential Bayesian filtering methods to detect and estimate both the number of neural sources and their corresponding parameters. Time-frequency based feature selection algorithms are combined with adaptive machine learning approaches to suppress physiological and non-physiological artifacts present in neural recordings. Adaptive processing and unsupervised clustering methods applied to neural recordings are also used to suppress neurostimulation artifacts and classify between various behavior tasks to assess the level of neurostimulation in patients.
For pathogen detection and identification, random peptide sequences and their properties are first uniquely mapped to highly-localized signals and their corresponding parameters in the time-frequency plane. Time-frequency signal processing methods are then applied to estimate antigenic determinants or epitope candidates for detecting and identifying potential pathogens.
For locating specific cognitive and behavioral information in different regions of the brain, neural recordings are processed using sequential Bayesian filtering methods to detect and estimate both the number of neural sources and their corresponding parameters. Time-frequency based feature selection algorithms are combined with adaptive machine learning approaches to suppress physiological and non-physiological artifacts present in neural recordings. Adaptive processing and unsupervised clustering methods applied to neural recordings are also used to suppress neurostimulation artifacts and classify between various behavior tasks to assess the level of neurostimulation in patients.
For pathogen detection and identification, random peptide sequences and their properties are first uniquely mapped to highly-localized signals and their corresponding parameters in the time-frequency plane. Time-frequency signal processing methods are then applied to estimate antigenic determinants or epitope candidates for detecting and identifying potential pathogens.
ContributorsMaurer, Alexander Joseph (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Bliss, Daniel (Committee member) / Chakrabarti, Chaitali (Committee member) / Kovvali, Narayan (Committee member) / Arizona State University (Publisher)
Created2016
Description
Due to vast resources brought by social media services, social data mining has
received increasing attention in recent years. The availability of sheer amounts of
user-generated data presents data scientists both opportunities and challenges. Opportunities are presented with additional data sources. The abundant link information
in social networks could provide another rich source in deriving implicit information
for social data mining. However, the vast majority of existing studies overwhelmingly
focus on positive links between users while negative links are also prevailing in real-
world social networks such as distrust relations in Epinions and foe links in Slashdot.
Though recent studies show that negative links have some added value over positive
links, it is dicult to directly employ them because of its distinct characteristics from
positive interactions. Another challenge is that label information is rather limited
in social media as the labeling process requires human attention and may be very
expensive. Hence, alternative criteria are needed to guide the learning process for
many tasks such as feature selection and sentiment analysis.
To address above-mentioned issues, I study two novel problems for signed social
networks mining, (1) unsupervised feature selection in signed social networks; and
(2) unsupervised sentiment analysis with signed social networks. To tackle the first problem, I propose a novel unsupervised feature selection framework SignedFS. In
particular, I model positive and negative links simultaneously for user preference
learning, and then embed the user preference learning into feature selection. To study the second problem, I incorporate explicit sentiment signals in textual terms and
implicit sentiment signals from signed social networks into a coherent model Signed-
Senti. Empirical experiments on real-world datasets corroborate the effectiveness of
these two frameworks on the tasks of feature selection and sentiment analysis.
received increasing attention in recent years. The availability of sheer amounts of
user-generated data presents data scientists both opportunities and challenges. Opportunities are presented with additional data sources. The abundant link information
in social networks could provide another rich source in deriving implicit information
for social data mining. However, the vast majority of existing studies overwhelmingly
focus on positive links between users while negative links are also prevailing in real-
world social networks such as distrust relations in Epinions and foe links in Slashdot.
Though recent studies show that negative links have some added value over positive
links, it is dicult to directly employ them because of its distinct characteristics from
positive interactions. Another challenge is that label information is rather limited
in social media as the labeling process requires human attention and may be very
expensive. Hence, alternative criteria are needed to guide the learning process for
many tasks such as feature selection and sentiment analysis.
To address above-mentioned issues, I study two novel problems for signed social
networks mining, (1) unsupervised feature selection in signed social networks; and
(2) unsupervised sentiment analysis with signed social networks. To tackle the first problem, I propose a novel unsupervised feature selection framework SignedFS. In
particular, I model positive and negative links simultaneously for user preference
learning, and then embed the user preference learning into feature selection. To study the second problem, I incorporate explicit sentiment signals in textual terms and
implicit sentiment signals from signed social networks into a coherent model Signed-
Senti. Empirical experiments on real-world datasets corroborate the effectiveness of
these two frameworks on the tasks of feature selection and sentiment analysis.
ContributorsCheng, Kewei (Author) / Liu, Huan (Thesis advisor) / Tong, Hanghang (Committee member) / Baral, Chitta (Committee member) / Arizona State University (Publisher)
Created2017
Description
In the last 15 years, there has been a significant increase in the number of motor neural prostheses used for restoring limb function lost due to neurological disorders or accidents. The aim of this technology is to enable patients to control a motor prosthesis using their residual neural pathways (central or peripheral). Recent studies in non-human primates and humans have shown the possibility of controlling a prosthesis for accomplishing varied tasks such as self-feeding, typing, reaching, grasping, and performing fine dexterous movements. A neural decoding system comprises mainly of three components: (i) sensors to record neural signals, (ii) an algorithm to map neural recordings to upper limb kinematics and (iii) a prosthetic arm actuated by control signals generated by the algorithm. Machine learning algorithms that map input neural activity to the output kinematics (like finger trajectory) form the core of the neural decoding system. The choice of the algorithm is thus, mainly imposed by the neural signal of interest and the output parameter being decoded. The various parts of a neural decoding system are neural data, feature extraction, feature selection, and machine learning algorithm. There have been significant advances in the field of neural prosthetic applications. But there are challenges for translating a neural prosthesis from a laboratory setting to a clinical environment. To achieve a fully functional prosthetic device with maximum user compliance and acceptance, these factors need to be addressed and taken into consideration. Three challenges in developing robust neural decoding systems were addressed by exploring neural variability in the peripheral nervous system for dexterous finger movements, feature selection methods based on clinically relevant metrics and a novel method for decoding dexterous finger movements based on ensemble methods.
ContributorsPadmanaban, Subash (Author) / Greger, Bradley (Thesis advisor) / Santello, Marco (Committee member) / Helms Tillery, Stephen (Committee member) / Papandreou-Suppappola, Antonia (Committee member) / Crook, Sharon (Committee member) / Arizona State University (Publisher)
Created2017
Description
The radar performance of detecting a target and estimating its parameters can deteriorate rapidly in the presence of high clutter. This is because radar measurements due to clutter returns can be falsely detected as if originating from the actual target. Various data association methods and multiple hypothesis filtering approaches have been considered to solve this problem. Such methods, however, can be computationally intensive for real time radar processing. This work proposes a new approach that is based on the unsupervised clustering of target and clutter detections before target tracking using particle filtering. In particular, Gaussian mixture modeling is first used to separate detections into two Gaussian distinct mixtures. Using eigenvector analysis, the eccentricity of the covariance matrices of the Gaussian mixtures are computed and compared to threshold values that are obtained a priori. The thresholding allows only target detections to be used for target tracking. Simulations demonstrate the performance of the new algorithm and compare it with using k-means for clustering instead of Gaussian mixture modeling.
ContributorsFreeman, Matthew Gregory (Author) / Papandreou-Suppappola, Antonia (Thesis advisor) / Bliss, Daniel (Thesis advisor) / Chakrabarti, Chaitali (Committee member) / Arizona State University (Publisher)
Created2016
Description
Artificial Intelligence, as the hottest research topic nowadays, is mostly driven by data. There is no doubt that data is the king in the age of AI. However, natural high-quality data is precious and rare. In order to obtain enough and eligible data to support AI tasks, data processing is always required. To be even worse, the data preprocessing tasks are often dull and heavy, which require huge human labors to deal with. Statistics show 70% - 80% of the data scientists' time is spent on data integration process. Among various reasons, schema changes that commonly exist in the data warehouse are one significant obstacle that impedes the automation of the end-to-end data integration process. Traditional data integration applications rely on data processing operators such as join, union, aggregation and so on. Those operations are fragile and can be easily interrupted by schema changes. Whenever schema changes happen, the data integration applications will require human labors to solve the interruptions and downtime. The industries as well as the data scientists need a new mechanism to handle the schema changes in data integration tasks. This work proposes a new direction of data integration applications based on deep learning models. The data integration problem is defined in the scenario of integrating tabular-format data with natural schema changes, using the cell-based data abstraction. In addition, data augmentation and adversarial learning are investigated to boost the model robustness to schema changes. The experiments are tested on two real-world data integration scenarios, and the results demonstrate the effectiveness of the proposed approach.
ContributorsWang, Zijie (Author) / Zou, Jia (Thesis advisor) / Baral, Chitta (Committee member) / Candan, K. Selcuk (Committee member) / Arizona State University (Publisher)
Created2021
Description
Predicting nonlinear dynamical systems has been a long-standing challenge in science. This field is currently witnessing a revolution with the advent of machine learning methods. Concurrently, the analysis of dynamics in various nonlinear complex systems continues to be crucial. Guided by these directions, I conduct the following studies. Predicting critical transitions and transient states in nonlinear dynamics is a complex problem. I developed a solution called parameter-aware reservoir computing, which uses machine learning to track how system dynamics change with a driving parameter. I show that the transition point can be accurately predicted while trained in a sustained functioning regime before the transition. Notably, it can also predict if the system will enter a transient state, the distribution of transient lifetimes, and their average before a final collapse, which are crucial for management. I introduce a machine-learning-based digital twin for monitoring and predicting the evolution of externally driven nonlinear dynamical systems, where reservoir computing is exploited. Extensive tests on various models, encompassing optics, ecology, and climate, verify the approach’s effectiveness. The digital twins can extrapolate unknown system dynamics, continually forecast and monitor under non-stationary external driving, infer hidden variables, adapt to different driving waveforms, and extrapolate bifurcation behaviors across varying system sizes. Integrating engineered gene circuits into host cells poses a significant challenge in synthetic biology due to circuit-host interactions, such as growth feedback. I conducted systematic studies on hundreds of circuit structures exhibiting various functionalities, and identified a comprehensive categorization of growth-induced failures. I discerned three dynamical mechanisms behind these circuit failures. Moreover, my comprehensive computations reveal a scaling law between the circuit robustness and the intensity of growth feedback. A class of circuits with optimal robustness is also identified. Chimera states, a phenomenon of symmetry-breaking in oscillator networks, traditionally have transient lifetimes that grow exponentially with system size. However, my research on high-dimensional oscillators leads to the discovery of ’short-lived’ chimera states. Their lifetime increases logarithmically with system size and decreases logarithmically with random perturbations, indicating a unique fragility. To understand these states, I use a transverse stability analysis supported by simulations.
ContributorsKong, Lingwei (Author) / Lai, Ying-Cheng (Thesis advisor) / Tian, Xiaojun (Committee member) / Papandreou-Suppappola, Antonia (Committee member) / Alkhateeb, Ahmed (Committee member) / Arizona State University (Publisher)
Created2023