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- Genre: Doctoral Dissertation
Description
Widespread adoption of smartphone based Mobile Medical Apps (MMAs) is opening new avenues for innovation, bringing MMAs to the forefront of low cost healthcare delivery. These apps often control human physiology and work on sensitive data. Thus it is necessary to have evidences of their trustworthiness i.e. maintaining privacy of health data, long term operation of wearable sensors and ensuring no harm to the user before actual marketing. Traditionally, clinical studies are used to validate the trustworthiness of medical systems. However, they can take long time and could potentially harm the user. Such evidences can be generated using simulations and mathematical analysis. These methods involve estimating the MMA interactions with human physiology. However, the nonlinear nature of human physiology makes the estimation challenging.
This research analyzes and develops MMA software while considering its interactions with human physiology to assure trustworthiness. A novel app development methodology is used to objectively evaluate trustworthiness of a MMA by generating evidences using automatic techniques. It involves developing the Health-Dev β tool to generate a) evidences of trustworthiness of MMAs and b) requirements assured code generation for vulnerable components of the MMA without hindering the app development process. In this method, all requests from MMAs pass through a trustworthy entity, Trustworthy Data Manager which checks if the app request satisfies the MMA requirements. This method is intended to expedite the design to marketing process of MMAs. The objectives of this research is to develop models, tools and theory for evidence generation and can be divided into the following themes:
• Sustainable design configuration estimation of MMAs: Developing an optimization framework which can generate sustainable and safe sensor configuration while considering interactions of the MMA with the environment.
• Evidence generation using simulation and formal methods: Developing models and tools to verify safety properties of the MMA design to ensure no harm to the human physiology.
• Automatic code generation for MMAs: Investigating methods for automatically
• Performance analysis of trustworthy data manager: Evaluating response time generating trustworthy software for vulnerable components of a MMA and evidences.performance of trustworthy data manager under interactions from non-MMA smartphone apps.
This research analyzes and develops MMA software while considering its interactions with human physiology to assure trustworthiness. A novel app development methodology is used to objectively evaluate trustworthiness of a MMA by generating evidences using automatic techniques. It involves developing the Health-Dev β tool to generate a) evidences of trustworthiness of MMAs and b) requirements assured code generation for vulnerable components of the MMA without hindering the app development process. In this method, all requests from MMAs pass through a trustworthy entity, Trustworthy Data Manager which checks if the app request satisfies the MMA requirements. This method is intended to expedite the design to marketing process of MMAs. The objectives of this research is to develop models, tools and theory for evidence generation and can be divided into the following themes:
• Sustainable design configuration estimation of MMAs: Developing an optimization framework which can generate sustainable and safe sensor configuration while considering interactions of the MMA with the environment.
• Evidence generation using simulation and formal methods: Developing models and tools to verify safety properties of the MMA design to ensure no harm to the human physiology.
• Automatic code generation for MMAs: Investigating methods for automatically
• Performance analysis of trustworthy data manager: Evaluating response time generating trustworthy software for vulnerable components of a MMA and evidences.performance of trustworthy data manager under interactions from non-MMA smartphone apps.
ContributorsBagade, Priyanka (Author) / Gupta, Sandeep K. S. (Thesis advisor) / Wu, Carole-Jean (Committee member) / Doupe, Adam (Committee member) / Zhang, Yi (Committee member) / Arizona State University (Publisher)
Created2015
Description
Monitoring vital physiological signals, such as heart rate, blood pressure and breathing pattern, are basic requirements in the diagnosis and management of various diseases. Traditionally, these signals are measured only in hospital and clinical settings. An important recent trend is the development of portable devices for tracking these physiological signals non-invasively by using optical methods. These portable devices, when combined with cell phones, tablets or other mobile devices, provide a new opportunity for everyone to monitor one’s vital signs out of clinic.
This thesis work develops camera-based systems and algorithms to monitor several physiological waveforms and parameters, without having to bring the sensors in contact with a subject. Based on skin color change, photoplethysmogram (PPG) waveform is recorded, from which heart rate and pulse transit time are obtained. Using a dual-wavelength illumination and triggered camera control system, blood oxygen saturation level is captured. By monitoring shoulder movement using differential imaging processing method, respiratory information is acquired, including breathing rate and breathing volume. Ballistocardiogram (BCG) is obtained based on facial feature detection and motion tracking. Blood pressure is further calculated from simultaneously recorded PPG and BCG, based on the time difference between these two waveforms.
The developed methods have been validated by comparisons against reference devices and through pilot studies. All of the aforementioned measurements are conducted without any physical contact between sensors and subjects. The work presented herein provides alternative solutions to track one’s health and wellness under normal living condition.
This thesis work develops camera-based systems and algorithms to monitor several physiological waveforms and parameters, without having to bring the sensors in contact with a subject. Based on skin color change, photoplethysmogram (PPG) waveform is recorded, from which heart rate and pulse transit time are obtained. Using a dual-wavelength illumination and triggered camera control system, blood oxygen saturation level is captured. By monitoring shoulder movement using differential imaging processing method, respiratory information is acquired, including breathing rate and breathing volume. Ballistocardiogram (BCG) is obtained based on facial feature detection and motion tracking. Blood pressure is further calculated from simultaneously recorded PPG and BCG, based on the time difference between these two waveforms.
The developed methods have been validated by comparisons against reference devices and through pilot studies. All of the aforementioned measurements are conducted without any physical contact between sensors and subjects. The work presented herein provides alternative solutions to track one’s health and wellness under normal living condition.
ContributorsShao, Dangdang (Author) / Tao, Nongjian (Thesis advisor) / Li, Baoxin (Committee member) / Hekler, Eric (Committee member) / Karam, Lina (Committee member) / Arizona State University (Publisher)
Created2016