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Description
The brain is a fundamental target of the stress response that promotes adaptation and survival but the repeated activation of the stress response has the potential alter cognition, emotion, and motivation, key functions of the limbic system. Three structures of the limbic system in particular, the hippocampus, medial prefrontal cortex (mPFC), and amygdala, are of special interest due to documented structural changes and their implication in post-traumatic stress disorder (PTSD). One of many notable chronic stress-induced changes include dendritic arbor restructuring, which reflect plasticity patterns in parallel with the direction of alterations observed in functional imaging studies in PTSD patients. For instance, chronic stress produces dendritic retraction in the hippocampus and mPFC, but dendritic hypertrophy in the amygdala, consistent with functional imaging in patients with PTSD. Some have hypothesized that these limbic region's modifications contribute to one's susceptibility to develop PTSD following a traumatic event. Consequently, we used a familiar chronic stress procedure in a rat model to create a vulnerable brain that might develop traits consistent with PTSD when presented with a challenge. In adult male rats, chronic stress by wire mesh restraint (6h/d/21d) was followed by a variety of behavioral tasks including radial arm water maze (RAWM), fear conditioning and extinction, and fear memory reconsolidation to determine chronic stress effects on behaviors mediated by these limbic structures. In chapter 2, we corroborated past findings that chronic stress caused hippocampal CA3 dendritic retraction. Importantly, we present new findings that CA3 dendritic retraction corresponded with poor spatial memory in the RAWM and that these outcomes reversed after a recovery period. In chapter 3, we also showed that chronic stress impaired mPFC-mediated extinction memory, findings that others have reported. Using carefully assessed behavior, we present new findings that chronic stress impacted nonassociative fear by enhancing contextual fear during extinction that generalized to a new context. Moreover, the generalization behavior corresponded with enhanced functional activation in the hippocampus and amygdala during fear extinction memory retrieval. In chapter 5, we showed for the first time that chronic stress enhanced amygdala functional activation during fear memory retrieval, i.e., reactivation. Moreover, these enhanced fear memories were resistant to protein synthesis interference to disrupt a previously formed memory, called reconsolidation in a novel attempt to weaken chronic stress enhanced traumatic memory. Collectively, these studies demonstrated the plastic and dynamic effects of chronic stress on limbic neurocircuitry implicated in PTSD. We showed that chronic stress created a structural and functional imbalance across the hippocampus, mPFC, and amygdala, which lead to a PTSD-like phenotype with persistent and exaggerated fear following fear conditioning. These behavioral disruptions in conjunction with morphological and functional imaging data reflect a chronic stress-induced imbalance between hippocampal and mPFC regulation in favor of amygdala function overdrive, and supports a novel approach for traumatic memory processing in PTSD.
ContributorsHoffman, Ann (Author) / Conrad, Cheryl D. (Thesis advisor) / Olive, M. Foster (Committee member) / Hammer, Jr., Ronald P. (Committee member) / Sanabria, Federico (Committee member) / Arizona State University (Publisher)
Created2013
Description
An introduction to neuroscientific thought aimed at an audience that is not educated in biology. Meant to be readable and easily understood by anyone with a high school education. The first section is completed in its entirety, with outlines for the proposed final sections to be completed over the next few years.
ContributorsNelson, Nicholas Alan (Author) / Olive, M. Foster (Thesis director) / Brewer, Gene (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / School of Life Sciences (Contributor) / School of Historical, Philosophical and Religious Studies (Contributor)
Created2014-05
ContributorsChandler, N. Kayla (Author) / Neisewander, Janet (Thesis director) / Sanabria, Federico (Committee member) / Olive, M. Foster (Committee member) / Barrett, The Honors College (Contributor) / College of Liberal Arts and Sciences (Contributor)
Created2013-05
Description
A review of current research on the relation between growth mindset and students with disabilities was completed. The goal for this project was to provide support for the idea that cultivating the growth mindset of students with disabilities could result in better academic outcomes and an overall improvement in the students’ lives including but not limited to self-efficacy skills, motivation, and dedication. Findings were used to design an evidence-based workbook for cultivating growth mindset in college students with disabilities.
ContributorsTrevino-Casias, Savannah (Author) / Bodman, Denise (Thesis director) / Van Vleet, Bethany (Committee member) / Corte, Corinne (Committee member) / College of Integrative Sciences and Arts (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
Music and emotions have been studied frequently in the past as well as music and memory. However, these three items don’t have as much research grouped together. Further, this research does not also encompass culture. In my research, the aim was to examine the relationship between music, memory, emotion, and culture of gender. The hypothesis was that women had more emotions linked to music than men. We gave 416 students an animal fluency task, a letter fluency task, six cultural fluency tasks, and a cultural identity survey. We used a t-test and created a graph to analyze my data. After administering my tasks, we found that women had recalled more adjectives linked to music than men. However, there was not a statistically significant difference between the number of adjectives with emotional valence between men and women, indicating that there was no relationship between gender and emotion in regards to music. The limitations on this study included the descriptions on how to complete the task, the cultural norms of the participants, and the disparity between the number of female and male participants. In a future study, it is necessary to be more specific in what is desired from the participants and to pay close attention to shifting gender norms. Further, we would also like to see how the results from future research can impact music therapy for memory-related mood disorders.
ContributorsLevin, Allison (Author) / Brewer, Gene (Thesis director) / Cohen, Adam (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / Department of Psychology (Contributor) / College of Integrative Sciences and Arts (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The relationship between user experience, learning, and psychology is complex. There are many rules and concepts that guide experience design. It is likely that some of the guidance is valid whereas other guidance is not. This explores some of that guidance and evaluates how they are linked to learning. Do the guidance’s made 25, 50, 100 years ago still hold true today? Additionally, the psychological background behind the way someone holds memory is important. Knowing how information is stored and processed helps educators provide the best learning experience possible. With an eye toward perception and cognition, this paper examines the relevance of the various pieces of guidance. The results suggest that, overall, this guidance is still valid and valuable to current learning trends and designs. This suggests that user experience designers for education need to pay attention to the guidance provided by psychology when designing learning management systems, placing content in a course, and choosing which aesthetics to follow.
ContributorsLapujade, Lily Ann (Author) / Branaghan, Russell (Thesis director) / Roscoe, Rod (Committee member) / Human Systems Engineering (Contributor, Contributor) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
The degree to which adolescents describe themselves as gender typical, as defined by their interests, activities, personal qualities, and other characteristics, is related to a broad range of adjustment indices. The goal of this thesis was to review studies conducted between 2000 and 2017 to provide a summary and critique of this research. A total of 18 studies were reviewed. The majority of findings indicate a positive association between gender typicality and beneficial adjustment outcomes, and a negative association between gender typicality and poor adjustment outcomes. Suggestions for future research and clinical implications of these findings are discussed.
ContributorsCohen, Alexandra Danielle (Author) / Updegraff, Kimberly (Thesis director) / Miller, Cindy (Committee member) / College of Integrative Sciences and Arts (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Asian Americans are facing unprecedented and growing mental health issues brought by anti-Asian Racism and other forms of hyper-visible oppression (Yellow Horse et al., 2021). In response to racism, one potential solution for bolstering mental health outcomes among Asian Americans is critical reflection. Critical reflection is the process through which oppressed and marginalized people critically analyze oppressive social conditions (e.g., racism, sexism, and more) and consider actions they can take to change them (Watts et al., 2011). Recent research suggests that, overall, there is a strong link between critical reflection and the well-being of youth of color (Maker Castro et al., 2022). However, this relationship may vary based on additional factors, such as strategies used to cope with racism-related stress. For instance, Asian Americans with lower critical reflection about racism (e.g., as evidenced by endorsement of colorblind racial ideology, or the belief that racial differences are irrelevant and racism no longer exists) had a higher tendency to use avoidant coping mechanisms to deal with discrimination (Yi et al., 2022; Lewis et al., 2019). Additionally, there is other evidence to support that Asian Americans who held more colorblind racial attitudes experienced less anxiety when challenged with ambiguous discrimination compared to Asian Americans who held less colorblind racial attitudes (Lee, 2016). Overall, the literature suggests the importance of the relationship between critical reflection and mental health. However, studies have yet to quantitatively explore the impacts of critical reflection and strategies to cope with discrimination on mental health outcomes among Asian Americans (Spanierman et al., 2021) and young adults (Maker Castro et al., 2022).
The current study seeks to address this gap in the literature by examining the role of strategies to cope with discrimination in the relationship between Asian Americans’ critical reflection and mental health outcomes. It is crucial to explore these factors as Asian American students continue to shoulder prejudice, stereotypes, and systemic racism in professional and educational institutions. We hypothesize that the relationship between critical reflection and mental health will be mediated by the strategies used to cope with discrimination. More specifically, we expect that low levels of critical reflection (as indicated by high levels of color-blind racial attitudes) are related to greater use of internalization, substance use, and detachment strategies to cope with discrimination, which is related to greater endorsement of depression, anxiety, and stress symptoms.
Data for this study were drawn from a larger study on college students’ experiences in ethnic studies courses. Participants were 288 Asian Americans recruited from ethnic studies courses at universities in various regions of the United States. During the first two weeks of their ethnic studies course, participants completed an online survey about their racial attitudes, critical consciousness, and psychological well-being. Mediation analyses will be conducted using the PROCESS macro (Hayes, 2022) on SPSS version 27. Critical reflection, as measured by participants’ total mean score on the Color-Blind Racial Attitudes Scale (Neville et al., 2000; Keum et al., 2018) will be included as the independent variable; subscale scores on the Coping with Discrimination Scale (Wei & Alvarez, 2010) will be mediators; and each subscale of the Depression, Anxiety, and Stress Scale (DASS-21; Henry & Crawford, 2005) will be the dependent variable in separate analyses. Relationships between the study variables and Asian subgroup (i.e., East, Southeast, and South Asian) will also be examined.
While analyses are currently ongoing, preliminary findings suggest that strategies to cope with discrimination and mental health outcomes vary between East Asians, Southeast Asians, and South Asians. Additionally, preliminary findings suggest that the use of substance use and detachment to cope with discrimination explains the relationship between low critical reflection and mental health outcomes.
Findings have implications for encouraging mental health specialists and educators to have open conversations about racism while helping those who experience discrimination cope in healthy ways. Thus, this research can contribute to improved psychological well-being of Asian American young adults.
ContributorsInocentes, Angeline (Author) / Ahn, Lydia (Thesis director) / Tran, Alisia (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / College of Integrative Sciences and Arts (Contributor) / School of Human Evolution & Social Change (Contributor)
Created2023-12
Description
Psychedelics have sparked widespread interest as they offer a potential new form of therapeutic treatment. This thesis paper explores the current and upcoming psychedelics that are being researched for their use in a therapeutic setting. The main substances discussed are lysergic acid diethylamide (LSD), methylenedioxymethamphetamine (ecstasy/molly/MDMA), and ketamine (esketamine). This paper also discusses the mechanism of action for each drug and the underlying research that has been found to support the ethical use of these substances alongside talk therapy
ContributorsPiemont, Sabrina (Author) / Jimenez Arista, Laura (Thesis director) / Ocampo Hoogasian, Rachel (Committee member) / Barrett, The Honors College (Contributor) / College of Integrative Sciences and Arts (Contributor)
Created2023-05
Description
This was an audiovisual exhibit showcasing 10 participants' portraits, artifact photos & audio stories. In a world full of polarization in the media and bias, my thesis project strives to highlight the similarities in our differences with stories from people of all different ages, backgrounds & lifestyles. And what topic is more human than home & belonging?
Additional info, audio & photos from the event can be found at the website used during the event: https://gsorian18.wixsite.com/sob-thesis2024
ContributorsSoriano, Gabrielle (Author) / Soares, Rebecca (Thesis director) / De La Torre, Monica (Committee member) / Paulesc, Marie-Louise (Committee member) / Barrett, The Honors College (Contributor) / School of Social and Behavioral Sciences (Contributor) / Department of Psychology (Contributor) / Hugh Downs School of Human Communication (Contributor) / College of Integrative Sciences and Arts (Contributor)
Created2024-05