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Description
Background: Both puberty and diets composed of high levels of saturated fats have been shown to result in central adiposity, fasting hyperinsulinemia, insulin resistance and impaired glucose tolerance. While a significantly insulinogenic phenotypic change occurs in these two incidences, glucose homeostasis does not appear to be affected. Methods: Male, Sprague-dawley rats were fed diets consisting of CHOW or low fat (LF), High Fat Diet and High Fat Diet (HFD) with supplementary Canola Oil (Monounsaturated fat). These rats were given these diets at 4-5 weeks old and given intraperitoneal and oral glucose tolerance tests(IPGTT; OGTT) at 4 and 8 weeks to further understand glucose and insulin behavior under different treatments. (IPGTT: LF-n=14, HFD-n=16, HFD+CAN-n=12; OGTT: LF-n=8, HFD-n=8, HFD+CAN-n=6). Results: When comparing LF fed rats at 8 weeks with 4 week glucose challenge test, area under the curve (AUC) of glucose was 1.2 that of 4 weeks. At 8 weeks, HFD fed rats AUCg was much greater than LF fed rats under both IPGTT and OGTT. When supplemented with Canola oil, HFD fed rats AUC returned to LF data range. Despite the alleviating glucose homeostasis affects of Canola oil the AUC of insulin curve, which was elevated by HFD, remained high. Conclusion: HFD in maturing rats elevates fasting insulin levels, increases insulin resistance and lowers glucose homeostasis. When given a monounsaturated fatty acid (MUFA) supplement fasting hyperinsulinemia, and late hyperinsulinemia still occur though glucose homeostasis is regained. For OGTT HFD also induced late hyper c-peptide levels and compared to LF and HFD+CAN, a higher c-peptide level over time.
ContributorsRay, Tyler John (Author) / Caplan, Michael (Thesis director) / Herman, Richard (Committee member) / Towner, Kali (Committee member) / Barrett, The Honors College (Contributor) / Department of Chemistry and Biochemistry (Contributor) / W. P. Carey School of Business (Contributor) / School of Human Evolution and Social Change (Contributor)
Created2015-05
Description
Type II diabetes is a serious, chronic metabolic disease that has serious impacts on both the health and quality of life in patients diagnosed with the disease. Type II diabetes is also a very prevalent disease both in the United States and around the world. There is still a lot that is unknown about Type II diabetes, and this study will aim to answer some of these questions. The question posed in this study is whether insulin resistance changes as a function of time after the start of a high fat diet. We hypothesized that peripheral insulin resistance would be observed in animals placed on a high fat diet; and peripheral insulin resistance would have a positive correlation with time. In order to test the hypotheses, four Sprague-Dawley male rats were placed on a high fat diet for 8 weeks, during which time they were subjected to three intraperitonal insulin tolerance tests ((NovoLogTM 1 U/kg). These three tests were conducted at baseline (week 1), week 4, and week 8 of the high fat diet. The test consisted of serially determining plasma glucose levels via a pin prick methodology, and exposing a droplet of blood to the test strip of a glucometer (ACCUCHEKTM, Roche Diagnostics). Two plasma glucose baselines were taken, and then every 15 minutes following insulin injection for one hour. Glucose disposal rates were then calculated by simply dividing the glucose levels at each time point by the baseline value, and multiplying by 100. Area under the curve data was calculated via definite integral. The area under the curve data was then subjected to a single analysis of variance (ANOVA), with a statistical significance threshold of p<0.05. The results of the study did not indicate the development of peripheral insulin resistance in the animals placed on a high fat diet. Insulin-mediated glucose disposal was about 50% at 30 minutes in all four animals, during all three testing periods. Furthermore, the ANOVA resulted in p=0.92, meaning that the data was not statistically significant. In conclusion, peripheral insulin resistance was not observed in the animals, meaning no determination could be made on the relation between time and insulin resistance.
ContributorsBrown, Kellen Andrew (Author) / Caplan, Michael (Thesis director) / Herman, Richard (Committee member) / School of Life Sciences (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
It is presently believed that brown adipose tissue (BAT) is an important tissue in the control of obesity because it has the propensity to increase energy expenditure. The purpose of this study was to attempt to quantify the thermogenesis of BAT when four rats were exposed to a progression of low-fat to high-fat diet. Exogenous norepinephrine (NE) injections (dose of 0.25 mg/kg i.p.) were administered in order to elicit a temperature response, where increases in temperature indicate increased activity. Temperatures were measured via temperature sensing transponders that had been inserted at the following three sites: interscapular BAT (iBAT), the abdomen (core), and lower back (reference). Data showed increased BAT activity during acute (2-3 weeks) high fat diet (HFD) in comparison to low fat diet (LFD), but a moderate to marked decrease in BAT activity during chronic HFD (6-8 weeks) when compared to acute HFD. This suggests that while a HFD may initially stimulate BAT in the short-term, a long-term HFD diet may have negative effects on BAT activation.
ContributorsSivak, Hanna (Author) / Sweazea, Karen (Thesis director) / Herman, Richard (Committee member) / Caplan, Michael (Committee member) / School of Life Sciences (Contributor) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
The degree to which adolescents describe themselves as gender typical, as defined by their interests, activities, personal qualities, and other characteristics, is related to a broad range of adjustment indices. The goal of this thesis was to review studies conducted between 2000 and 2017 to provide a summary and critique of this research. A total of 18 studies were reviewed. The majority of findings indicate a positive association between gender typicality and beneficial adjustment outcomes, and a negative association between gender typicality and poor adjustment outcomes. Suggestions for future research and clinical implications of these findings are discussed.
ContributorsCohen, Alexandra Danielle (Author) / Updegraff, Kimberly (Thesis director) / Miller, Cindy (Committee member) / College of Integrative Sciences and Arts (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2017-05
Description
Adaptive thermogenesis is an innate mechanism that assists the body in controlling its core temperature that can be stimulated in two ways: cold and diet. When adaptive thermogenesis is stimulated through diet, the metabolic rate of the body should increase and the metabolic efficiency of the body should decrease. This activation should, theoretically, help to control weight gain. A protocol was developed to study four male Sprague-Dawley rats throughout a fourteen week period through the measurement of brown adipose tissue blood flow and brown adipose tissue, back, and abdomen temperatures to determine if diet induced thermogenesis existed and could be activated through norepinephrine. The sedative used to obtain blood flow measurements, ketamine, was discovered to induce a thermal response prior to the norepinephrine injection by mimicking the norepinephrine response in the sympathetic nervous system. This discovery altered the original protocol to exclude an injection of norepinephrine, as this injection would have no further thermal effect. It was found that ketamine sedation excited diet induced thermogenesis in periods of youth, low fat diet, and early high fat diet. The thermogenic capacity was found to be at a peak of 2.1 degrees Celsius during this time period. The data also suggested that the activation of diet induced thermogenesis decreased as the period of high fat diet increased, and by week 4 of the high fat diet, almost all evidence of diet induced thermogenesis was suppressed. This indicated that diet induced thermogenesis is time and diet dependent. Further investigation will need to be made to determine if prolonged high fat diet or age suppress diet induced thermogenesis.
ContributorsJayo, Heather Lynn (Author) / Caplan, Michael (Thesis director) / Herman, Richard (Committee member) / Chemical Engineering Program (Contributor) / Barrett, The Honors College (Contributor)
Created2016-12
Description
Psychedelics have sparked widespread interest as they offer a potential new form of therapeutic treatment. This thesis paper explores the current and upcoming psychedelics that are being researched for their use in a therapeutic setting. The main substances discussed are lysergic acid diethylamide (LSD), methylenedioxymethamphetamine (ecstasy/molly/MDMA), and ketamine (esketamine). This paper also discusses the mechanism of action for each drug and the underlying research that has been found to support the ethical use of these substances alongside talk therapy
ContributorsPiemont, Sabrina (Author) / Jimenez Arista, Laura (Thesis director) / Ocampo Hoogasian, Rachel (Committee member) / Barrett, The Honors College (Contributor) / College of Integrative Sciences and Arts (Contributor)
Created2023-05
Description
Asian Americans are facing unprecedented and growing mental health issues brought by anti-Asian Racism and other forms of hyper-visible oppression (Yellow Horse et al., 2021). In response to racism, one potential solution for bolstering mental health outcomes among Asian Americans is critical reflection. Critical reflection is the process through which oppressed and marginalized people critically analyze oppressive social conditions (e.g., racism, sexism, and more) and consider actions they can take to change them (Watts et al., 2011). Recent research suggests that, overall, there is a strong link between critical reflection and the well-being of youth of color (Maker Castro et al., 2022). However, this relationship may vary based on additional factors, such as strategies used to cope with racism-related stress. For instance, Asian Americans with lower critical reflection about racism (e.g., as evidenced by endorsement of colorblind racial ideology, or the belief that racial differences are irrelevant and racism no longer exists) had a higher tendency to use avoidant coping mechanisms to deal with discrimination (Yi et al., 2022; Lewis et al., 2019). Additionally, there is other evidence to support that Asian Americans who held more colorblind racial attitudes experienced less anxiety when challenged with ambiguous discrimination compared to Asian Americans who held less colorblind racial attitudes (Lee, 2016). Overall, the literature suggests the importance of the relationship between critical reflection and mental health. However, studies have yet to quantitatively explore the impacts of critical reflection and strategies to cope with discrimination on mental health outcomes among Asian Americans (Spanierman et al., 2021) and young adults (Maker Castro et al., 2022).
The current study seeks to address this gap in the literature by examining the role of strategies to cope with discrimination in the relationship between Asian Americans’ critical reflection and mental health outcomes. It is crucial to explore these factors as Asian American students continue to shoulder prejudice, stereotypes, and systemic racism in professional and educational institutions. We hypothesize that the relationship between critical reflection and mental health will be mediated by the strategies used to cope with discrimination. More specifically, we expect that low levels of critical reflection (as indicated by high levels of color-blind racial attitudes) are related to greater use of internalization, substance use, and detachment strategies to cope with discrimination, which is related to greater endorsement of depression, anxiety, and stress symptoms.
Data for this study were drawn from a larger study on college students’ experiences in ethnic studies courses. Participants were 288 Asian Americans recruited from ethnic studies courses at universities in various regions of the United States. During the first two weeks of their ethnic studies course, participants completed an online survey about their racial attitudes, critical consciousness, and psychological well-being. Mediation analyses will be conducted using the PROCESS macro (Hayes, 2022) on SPSS version 27. Critical reflection, as measured by participants’ total mean score on the Color-Blind Racial Attitudes Scale (Neville et al., 2000; Keum et al., 2018) will be included as the independent variable; subscale scores on the Coping with Discrimination Scale (Wei & Alvarez, 2010) will be mediators; and each subscale of the Depression, Anxiety, and Stress Scale (DASS-21; Henry & Crawford, 2005) will be the dependent variable in separate analyses. Relationships between the study variables and Asian subgroup (i.e., East, Southeast, and South Asian) will also be examined.
While analyses are currently ongoing, preliminary findings suggest that strategies to cope with discrimination and mental health outcomes vary between East Asians, Southeast Asians, and South Asians. Additionally, preliminary findings suggest that the use of substance use and detachment to cope with discrimination explains the relationship between low critical reflection and mental health outcomes.
Findings have implications for encouraging mental health specialists and educators to have open conversations about racism while helping those who experience discrimination cope in healthy ways. Thus, this research can contribute to improved psychological well-being of Asian American young adults.
ContributorsInocentes, Angeline (Author) / Ahn, Lydia (Thesis director) / Tran, Alisia (Committee member) / Barrett, The Honors College (Contributor) / Department of Psychology (Contributor) / College of Integrative Sciences and Arts (Contributor) / School of Human Evolution & Social Change (Contributor)
Created2023-12
Description
A review of current research on the relation between growth mindset and students with disabilities was completed. The goal for this project was to provide support for the idea that cultivating the growth mindset of students with disabilities could result in better academic outcomes and an overall improvement in the students’ lives including but not limited to self-efficacy skills, motivation, and dedication. Findings were used to design an evidence-based workbook for cultivating growth mindset in college students with disabilities.
ContributorsTrevino-Casias, Savannah (Author) / Bodman, Denise (Thesis director) / Van Vleet, Bethany (Committee member) / Corte, Corinne (Committee member) / College of Integrative Sciences and Arts (Contributor) / Sanford School of Social and Family Dynamics (Contributor) / Department of Psychology (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05
Description
The relationship between user experience, learning, and psychology is complex. There are many rules and concepts that guide experience design. It is likely that some of the guidance is valid whereas other guidance is not. This explores some of that guidance and evaluates how they are linked to learning. Do the guidance’s made 25, 50, 100 years ago still hold true today? Additionally, the psychological background behind the way someone holds memory is important. Knowing how information is stored and processed helps educators provide the best learning experience possible. With an eye toward perception and cognition, this paper examines the relevance of the various pieces of guidance. The results suggest that, overall, this guidance is still valid and valuable to current learning trends and designs. This suggests that user experience designers for education need to pay attention to the guidance provided by psychology when designing learning management systems, placing content in a course, and choosing which aesthetics to follow.
ContributorsLapujade, Lily Ann (Author) / Branaghan, Russell (Thesis director) / Roscoe, Rod (Committee member) / Human Systems Engineering (Contributor, Contributor) / College of Integrative Sciences and Arts (Contributor) / Barrett, The Honors College (Contributor)
Created2020-05
Description
Music and emotions have been studied frequently in the past as well as music and memory. However, these three items don’t have as much research grouped together. Further, this research does not also encompass culture. In my research, the aim was to examine the relationship between music, memory, emotion, and culture of gender. The hypothesis was that women had more emotions linked to music than men. We gave 416 students an animal fluency task, a letter fluency task, six cultural fluency tasks, and a cultural identity survey. We used a t-test and created a graph to analyze my data. After administering my tasks, we found that women had recalled more adjectives linked to music than men. However, there was not a statistically significant difference between the number of adjectives with emotional valence between men and women, indicating that there was no relationship between gender and emotion in regards to music. The limitations on this study included the descriptions on how to complete the task, the cultural norms of the participants, and the disparity between the number of female and male participants. In a future study, it is necessary to be more specific in what is desired from the participants and to pay close attention to shifting gender norms. Further, we would also like to see how the results from future research can impact music therapy for memory-related mood disorders.
ContributorsLevin, Allison (Author) / Brewer, Gene (Thesis director) / Cohen, Adam (Committee member) / Sanford School of Social and Family Dynamics (Contributor) / Department of Psychology (Contributor) / College of Integrative Sciences and Arts (Contributor) / School of International Letters and Cultures (Contributor) / Barrett, The Honors College (Contributor)
Created2019-05