In 2009, Shoukhrat Mitalipov, Masahito Tachibana, and their team of researchers developed the technology of mitochondrial gene replacement therapy to prevent the transmission of a mitochondrial disease from mother to offspring in primates. Mitochondria contain some of the body's genetic material, called mitochondrial DNA. Occasionally, the mitochondrial DNA possesses mutations. Mitalipov and Tachibana, researchers at the Oregon National Primate Research Center in Beaverton, Oregon, developed a technique to remove the nucleus of the mother and place it in a donor oocyte, or immature egg cell, with healthy mitochondria. The resulting offspring contain the genetic material of three separate individuals and do not have the disease. Mitalipov and Tachibana's technology of mitochondrial gene replacement built on decades of research by different scientists and enables researchers to prevent the transmission of human mitochondrial diseases from mother to offspring.
Details
- Shoukhrat Mitalipov and Masahito Tachibana's Mitochondrial Gene Replacement Therapy Technique
- Lee, Giselle (Author)
- Gleason, Kevin M. (Editor)
- Arizona State University. School of Life Sciences. Center for Biology and Society. Embryo Project Encyclopedia. (Publisher)
- Arizona Board of Regents (Publisher)
- Technology
- monkeys
- Gurdon, J. B. (John Bertrand)
- Briggs, Robert, -1983
- King, Thomas J. (Thomas Joseph), 1921-2000
- rhesus macaque
- Embryonic Stem Cells
- Mitochondrial Diseases
- Oocytes
- Chromosome Aberrations
- Neurodegenerative Diseases
- Muscular Diseases
- DNA, Mitochondrial
- Chromosomes
- Nuclear Transfer Techniques
- Meiosis
- Technologies
- Spindle Transfer