Description
The risk of developing cancer should theoretically increase with both the number of cells and the lifespan of an organism. However, gigantic animals do not get more cancer than humans, suggesting that super-human cancer suppression has evolved numerous times across the tree of life. This is the essence and promise of Peto’s Paradox. We discuss what is known about Peto’s Paradox and provide hints of what is yet to be discovered.
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Title
- Peto’s Paradox: How Has Evolution Solved the Problem of Cancer Prevention?
Contributors
- Tollis, Marc (Author)
- Boddy, Amy (Author)
- Maley, Carlo (Author)
- College of Liberal Arts and Sciences (Contributor)
Date Created
The date the item was original created (prior to any relationship with the ASU Digital Repositories.)
2017-07-13
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Identifier
- Digital object identifier: 10.1186/s12915-017-0401-7
- Identifier TypeInternational standard serial numberIdentifier Value1741-7007
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- The electronic version of this article is the complete one and can be found online at: https://bmcbiol.biomedcentral.com/articles/10.1186/s12915-017-0401-7, opens in a new window
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Tollis, M., Boddy, A. M., & Maley, C. C. (2017). Peto’s Paradox: how has evolution solved the problem of cancer prevention? BMC Biology, 15(1). doi:10.1186/s12915-017-0401-7